public-health-2017_posters-accepted-abstracts

13 / 24

Page 69
Notes:
conferenceseries.com
March 22-23, 2017 | Rome, Italy
2nd World Congress on
Public Health & Nutrition
Volume 7, Issue 1 (Suppl) J Community Med Health Educ 2017
ISSN: 2161-0711, JCMHE an open access journal Public Health 2017
March 22-23, 2017
Arg72pro POLYMORPHISM OF Tp53 GENE IS RELATED TO CARDIOVASCULAR RISK
FACTORS AMONG CROATIAN SENESCENT MEN
Petra Krajacica, Tatjana Skaric-Jurica, Zeljka Tomasa, Matea Zajc Petranovica and Nina Smolej Narancica
aInstitute for Anthropological Research, Croatia
The p53 tumor suppressor protein, often termed the genome’s guardian, has a critical role in cell cycle, apoptosis, cell senescence,
DNA repair and metabolism. Animal and human studies have identified TP53 gene as one of the most important candidate genes
involved in longevity. Here, we investigated the associations of Arg72Pro polymorphism of TP53 gene with indicators of biological
age in 324 people aged 85+ yrs. Univariate and multivariate analyses of wide spectrum of variables associated with health status
included noninvasive biometric measurements, biochemical blood tests and self-rated health. In univariate analyses Arg/Arg was
related with higher body mass (skinfold thickness, upper arm and waist circumferences) and with higher fasting blood glucose. T-test,
ANOVA/PostHoc test results showed a significant positive association of Arg/Arg genotype with anthropometric nutritional status
variables as well as with fasting glucose level (cardiovascular risk factors) in elderly men but not in women. Sex-specific principal
component analysis encompassing 40 variables extracted four significant factors, among which the first factor represented body
mass and composition while the second one represented general health. Although the two factors had almost identical structure
in both sexes, the t-test (p = 0.031), ANOVA (p = 0.046) and PostHoc test (p=0.018) revealed significant association of Arg72Pro
polymorphism only with the factor of general health in men, indicating that Arg/Arg was the risk and Arg/Pro was the protective
genotype. Namely, Arg/Pro heterozygote carriers had better scores in personal independence, motility and self-rated health, suffered
less from chronic and acute illness and used fewer medications. We suggest that further research should also be directed towards the
investigation of gender specific influence of TP53 gene on different health-related traits. In conclusion, our results indicate the role of
Arg72Pro polymorphism in health-related traits in men of very old age, but its role in longevity remains to be elucidated.
Biography
Petra Krajacic is Ph.D. student at Faculty of science (Department of Biology, Zagreb University, Croatia). In her dissertation she conducted an association study
of four most important polymorphisms of longevity genes (p53, IL-6, TNF, SIRT1) and diverse phenotypic traits, like motility, independence, life satisfaction and
the presence of age- related disease, of 325 very old age people (85+). This research is a part of a Complex traits variation and health in children, adults and
centenarians project founded by the Ministry of Science, Education and Sports.
Petra Krajacic et al., J Community Med Health Educ 2017, 7:1 (Suppl)