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Page 35
Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Circulating betatrophin in relation tometabolic, inflammatory Parameters, and oxidative stress in patients
with type 2 Diabetes mellitus
Bland Bayar Khaleel
h
, Alan Bapeer Hassan
a
, Sherwan Ferman Salih
b
, Israa Issa Hassan
a
, Farsat Saeed Saadi
d
,
Deldar Morad Abdulah
e
*, Idris Haji Ahmed
f
and
Sherzad Majeed Taher
g
a,b,e,g
University of Duhok, Iraq
d
Duhok General Directorate of Health, Iraq
f
Azadi Teaching Hospital, Iraq
h
Preventive Health Directorate, Iraq
Aims
: Recently, it was suggested that betatrophin has a role in controlling pancreatic b cell proliferation and lipid
metabolism, however, its role in human subjects has not been established yet. The predicting role of betatrophin and
MDA along with other biochemical indicators in type 2 diabetes mellitus (T2DM) in a sample of the Iraqi population
was examined in the present investigation.
Methods
: A total of 31 patients diagnosed with T2DM and 30 adult subjects without diabetes were matched in age
and gender in a case-control study. Logistic and linear regression models were performed
to examine the role of MDA and betatrophin in T2DM and triglyceride, respectively.
Results
: The study confirmed a higher concentration of LDL (124.45 vs. 102.70 mg/dL; P ¼.001) and TG (191.13 vs.
103.83 mg/dL; P < .0001), insulin (18.40 vs. 10.97 mU/mL; P < .0001), and Hs. CRP (5.39 vs. 2.80 mg/L; P ¼.033) in
diabetic patients compared to the controls. No significant difference in betatrophin and MDA was found between
diabetic patients and non-diabetic healthy subjects. The study
Showed triglyceride as the only predictor of T2DM (P ¼.028). Similarly, total cholesterol (P < .0001), HDL (P ¼.001),
LDL (P < .0003), and MDA (P ¼.010) were shown as predictors of triglyceride in diabetic patients.
Conclusion
: The present study that triglyceride is a direct and MDA is an indirect predictor for T2DM.
Recent Publications:
1. HuH, SunW, Yu S, Hong X, QianW, Tang B, et al. Increased circulating levels of betatrophin in newly diagnosed
type 2 diabetic patients. Diabetes Care 2014:DC_140602.
2. Vetere A, Choudhary A, Burns SM, Wagner BK. Targeting the pancreatic b-cell to treat diabetes. Nat Rev Drug
Discov 2014;13(4):nrd4231.
3. Yi P, Park J-S, Melton DA. RETRACTED: betatrophin: a hormone that controls pancreatic b cell proliferation.
Elsevier; 2013.
4. [5] Zhang R, Lipasin. A novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride
levels. Biochem Biophys Res Commun 2012; 424(4):786e92.
5. Yi P, Park J-S, Melton DA. Perspectives on the activities of ANGPTL8/betatrophin. Cell 2014;159(3):467e8.
6. [23] Fenzl A, Itariu BK, Kosi L, Fritzer-Szekeres M, Kautzky-Willer A, Stulnig TM, et al. Circulating betatrophin
correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals.
Diabetologia 2014;57(6):1204e8.
Bland Bayar Khaleel et al., Clin Pharmacol Biopharm, Volume 08