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Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Forming statin response in patients with coronary heart disease in presence of acute respiratory viral
infections by means of genetic markers
Galina S. Mal
Kursk State Medical University, Russia
Statement of the Problem:
Development of CHD associated with atherosclerosis. One of the main pathogenetic
causes of atherosclerosis development is inflammation, being an important atherogenesis component. Any acute
infection may be the etiological factor which activates chronic inflammation in the atherosclerotic plaque, involving
the cytokine system. A number of studies demonstrate the relation between an increase of cytokine level and the signs
of atherosclerosis destabilization and CHD. The purpose of this study is to describe the drug response variability in
CHD patients with an acute viral infection.
Methodology & Theoretical Orientation:
The study involved 170 CHD patients, 120 of whom also had infections
(ARVI). The LDL-C and cholesterol levels were determined in the blood serum using an enzymatic method.
Genotyping of polymorphisms IL-1β –511C>T, IL-6 –174G>C, IL-4 –589C>T, IL-10 –1082G>А was performed
using a PCR method on the CFX96 Bio-Rad Laboratories amplifier (USA).
Findings:
Carriership of –511TT genotype were diagnosed with the lowest LDL-C level and a high HDL-C level
(p<0.05), which confirmed the hypolipidemic statin effect. Carriers of –511СС genotype had the increased LDL-C
levels. Carriership homozygous –1082GG genotype demonstrated the association with the level of Cholesterol
(P=0.003). When the anti-inflammatory cytokine (IL-4, IL-10) level increased, C level decreased (P<0.05). The
analysis of correlation between pro- /anti-inflammatory cytokine gene genotypes revealed the activity of genotypes
–511TT (IL-1β gene), –174CC (IL-6 gene), –589TT (IL-4 gene), and –1082GG (IL-10 gene) in maintaining chronic
inflammation stability (P=0.012).
Conclusion & Significance:
The obtained correlations contributed to the preparation of personalized HLP
pharmacotherapy algorithm in CHD patients in presence of ARVI. The presence of heterozygous –511CT genotype
for –511C>T polymorphism of the IL-1β gene, homozygous –174GG genotype for –174G>C polymorphism of the
IL-6 gene, and homozygous –1082AA genotype for polymorphism –1082G>A of the IL-10 gene did not lead to
reaching the target LDL-C level.
Recent Publications:
1. Babu BM, Reddy BP, Priya VH et al. (2012) Cytokine gene polymorphisms in the susceptibility to acute
coronary syndrome. Genetic Testing and Molecular Biomarkers 16(5): 359-365
2. Chen L, Liu L, Hong K et al. (2012) Three genetic polymorphisms of homocysteine-metabolizing enzymes and
risk of coronary heart disease: a meta-analysis based on 23 case-control studies. DNA and Cell Biology 31(2):
238-249
3. Guan X, Yang W, Sun X et al. (2012) Association of influenza virus infection and inflammatory cytokines with
acute myocardial infarction.
4. Inflammation Research 61(6): 591-598
5. Loppnow Н, Zhang L, Buerke M et al. (2011) Statins potently reduce the cytokine-mediated IL-6 release in
Galina S. Mal, Clin Pharmacol Biopharm, Volume 08