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Volume 7, Issue 4 (Suppl)
Clin Exp Pharmacol
ISSN: 2161-1459 CPECR, an open access journal
Pharmacology Congress 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
8
th
World Congress on
Pharmacology and Toxicology
The role of nicotinic receptors in the effects of galangin in the Morris water maze
Fatma Sultan Kilic, Sule Aydin, Engin Yildirim, Setenay Oner, Kevser Erol
and
Bilgin Kaygisiz
Eskisehir Osmangazi University, Turkey
Introduction &Aim:
Enhancing cholinergic transmission is suggested to improve cognitive functions. We aimed to investigate
the effects of galangin, a flavonoid compound that is reported to inhibit acetylcholinesterase enzyme, on mecamylamine-
induced spatial memory impairments in rats.
Methods:
Morris water maze test was used to investigate the spatial memory. Galangin 50 (100 mg/kg) was administered
acutely 30 minutes before the impairment of spatial memory by a nicotinic receptor antagonist (mecamylamine injection).
Donepezil (1 mg/kg) used as a reference drug. Distance to platform and time spent in escape platform quadrant were recorded
and analyzed with Ethovision XT version 9.0 (Noldus, Wageningen, Netherlands). Results were statistically analyzed with one-
way ANOVA.
Results:
Mecamylamine significantly increased the distance to platform and decreased the time spent in the escape platform
quadrant compared to control group. Galangin 100, but not 50 mg/kg significantly decreased the distance to platform and
increased the time spent in the escape platform quadrant compared to mecamylamine group comparable to donepezil 1 mg/kg.
Conclusion:
Galangin 100 g/kg may improve memory comparable to donepezil and nicotinic receptors may be involved in
this effect.
Biography
Fatma Sultan Kilic has completed her PhD from Anadolu University, Turkey. She has been working as an Academic Member and also contunuing her PhD at
Faculty of Education. She has published more than 45 papers in reputed journals.
fskilic@ogu.edu.trFatma Sultan Kilic et al., Clin Exp Pharmacol 2017, 7:4 (Suppl)
DOI: 10.4172/2161-1459-C1-020