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.com
Volume 7, Issue 4 (Suppl)
Clin Exp Pharmacol
ISSN: 2161-1459 CPECR, an open access journal
Pharmacology Congress 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
8
th
World Congress on
Pharmacology and Toxicology
Exploring ethnopharmacological potential of Australian native old man saltbush and wattle seed with
untargeted metabolic profiling and structural elucidation with mass spectrometry
Rashida Bashir
1
, Andrew Jones
1
, Andrew Shalliker
1
, Enzo Palombo
2
and
Peter Mahon
2
1
University of Western Sydney, Australia
2
Swinburne University of Technology, Australia
C
urrently, there are 119 drugs of known structure that are still extracted from higher plants and used globally in allopathic
medicine. Ethnomedical and traditional medicinal use of Australian aboriginal plants can provide information that
is useful to pre-screen them for experimental pharmacological studies. Australian aboriginal people use old man saltbush
topically as a medicine for cuts and stings and wattle seeds as a mild sedative for rheumatism or indigestion. This study
intended to attract the attention of ethnopharmacologists to focus on the unexplored potential of both edible plants. Recent
advances in bioanalytical technologies have emerged as a critical tool in the process of drug discovery and development. Non-
targeted metabolomics with Reaction Flow Chromatography-Post Column detection-Ferric reducing Antioxidant potential
assay (RF-PCD-FRAP) and LC-ESI-MS analysis implies that Australian native saltbush and wattle seed are rich sources
of antioxidants. Underivatized and derivatized reactions were simultaneously monitored to attain information of complex
samples. Analytes were identified by MS and MS
2
with the ESI mass spectra under the same conditions in both positive and
negative ionization modes. Isorhamnetin, Rhamnetin, Asarone, Nookatone, Brevifolin and Apocynin Quinic acid, Citric acid,
Gallic acid, Quinovic acid, β-D-glucoside, D-Pantothenic acid and 4”-0-beta glucose 4-p-Coumaroylquinic acid were the
main bioactives found within samples, which may be responsible for their well-known therapeutic roles of these plants. Both
samples have exhibited superior antioxidant capacity and comprise predominantly of flavonols, anthocyanin, phenolic acids
and contains bioactives with known therapeutic potential in cardiovascular, neurodegenerative and other chronic diseases that
play a major role in the prevention/delay of diseases.
Biography
Rashida Bashir has previously completed Masters of Biotechnology and Bachelor of Pharmaceutical Sciences. She has recently submitted her PhD thesis in
the area of Natural Products and Bioanalytical Chemistry under the supervision of Dr. Peter Mahon and Professor Enzo Palombo.
rbashir@swin.edu.auRashida Bashir et al., Clin Exp Pharmacol 2017, 7:4 (Suppl)
DOI: 10.4172/2161-1459-C1-020