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Volume 5 Issue 4(Suppl) Clin Pharmacol Biopharm
ISSN: 2167-065X CPB, an open access journal
Page 34
Pharma & Clinical Pharmacy Congress 2016
November 07-09, 2016
conferenceseries.com
November 07-09, 2016 Las Vegas, Nevada, USA
4th International
Pharma & Clinical Pharmacy Congress
Gaku Fukuhara, Clin Pharmacol Biopharm 2016, 5:4(Suppl)
Pharmaceutical Oligosaccharide sensing by a chemical approach
S elective sensing of oligosaccharides in aqueous media is a challenge
in current chemistry due to their heavy hydration and stereochemical
diversity. us, the develop¬ment of selective saccharide sensor that
functions in aqueous media is of particular signi cance and bene t not only
from the scienti c but also from the application point of view.
In this study, we synthesized reporter-modi ed curdlan (DABz-Cur)
as a saccharide chemosensor, and investi¬gated its abilities for sensing a
variety of oligosaccharides by using circular dichroism spectroscopy to nd
a speci cally high sensitivity for one of tetrasaccharides, i.e. acarbose shown
in Figure 1a. Acarbose is a drug to treat type-2 diabetes mellitus and obesity
by inhibiting α-glucosidase that releases glucose from higher carbohydrates,
and therefore its detection is of particular signi cance from the diagnostic
viewpoint. e saccharide sensing results of further interesting approach by
an in situ hybrid sensor with Cur and PyPT in Figure 1b and their detailed
supramolecular complexation will be discussed.
Biography
Gaku Fukuhara was born in Hyogo, Japan in 1979. He earned his PhD degree in 2007 (Osaka University). After earning PhD degree, he moved to Massachusetts
Institute of Technology to work with Professor Timothy M. Swager. He is currently an Assistant Professor in Osaka University since 2008. Now, he is appointed as
a Guest Editor of Journal of Photochemistry and Photobiology A: Chemistry. He is an author of 77 papers, patents, books, and accounts.
Gaku Fukuhara
Osaka University, Japan