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conferenceseries.com
Volume 7, Issue 1 (Suppl) J Clin Exp Pathol
ISSN: 2161-0681 JCEP, an open access journal
Pediatric Pathology & Laboratory Medicine 2017
March 15-16, 2017
March 15-16, 2017 London, UK
12th International Conference on
Pediatric Pathology & Laboratory Medicine
Evaluation of human epidermal growth factor receptor (HER-2/neu) in gastric adenocarcinoma: A study
from South Asia region
Asma Shabbir, Muhammad Asif Qureshi, Talat Mirza and Abdullah Bin Khalid
Jinnah Sindh Medical University, Pakistan
Background & Aim: Gastric cancer is the third leading cause of cancer mortality worldwide. Human epidermal growth factor (HER-
2/neu) has shown strong therapeutic implication in breast cancer. Expression of HER-2/neu in gastric cancer has been reported from
across the world, it is still unknown from South Asia region. The aim of this study is to evaluate HER-2/neu expression in gastric
adenocarcinomas and to correlate with various clinicopathological variables.
Patients & Method: A total of 95 consecutive patients undergoing endoscopic biopsy or gastrectomy were recruited in this study
after institutional ethical approval. Clinicopathological parameters of all patients were recorded and hematoxylin and eosin (H&E)
staining was performed. Expression of HER-2/neu was investigated by immunohistochemistry using α-HER-2 antibody. Hofmann
validation scoring system was used and its association was seen with various clinicopathological variables including age, gender,
histopathological type, grade and stage of the tumor.
Results: HER-2/neu over expression was found in 21 (22.1%) cases from the total of 95 gastric adenocarcinomas. HER-2/neu was
significantly expressed in low grade gastric cancer (p=0.030). Although there was no significant difference between HER-2/neu
expression and other variables, HER-2/neu score 3+ was higher in females, age >60 years, Laurens intestinal type and IIIC stage.
Conclusion: HER-2/neu is expressed in a limited group of gastric cancer patients in Pakistani population. Our findings indicate a
significant strong association of HER-2/neu expression with low grades of gastric cancer.
Biography
Asma Shabbir has done her MBBS from B J Medical College, Pune, India. She has done her Post-graduation from Dow International Medical College, Karachi,
Pakistan. She has a passion towards research and concerned for better prognosis of the patient. She has presented her research work in many conferences.
Recently, she received the Young Researcher Award at the International Conference of Digestive Diseases in Dubai 2016. She is a member of different scientific
and research associations. At present, she is working as a Researcher and as an Assistant Professor in the Department of Pathology, Jinnah Sindh Medical
University, Pakistan.
Asma Shabbir et al., J Clin Exp Pathol 2017, 7:1 (Suppl)