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Volume 8
Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X
Page 52
JOINT EVENT
Pediatric Gastro 2018
Digestive Diseases 2018
October 22-23, 2018
October 22-23, 2018 Berlin, Germany
3
rd
International Conference on
Digestive and Metabolic Diseases
Pediatric Gastroenterology Hepatology & Nutrition
13
th
International Conference on
&
Neutrophil to lymphocyte ratio: Predictive marker for assessing the severity of ulcerative colitis?
Ovidiu Fratila
University of Oradea, Romania
Introduction:
Several markers have been proposed along the time to assess the severity and the progression of ulcerative colitis
(UC) but they are expensive and some of them not specific for intestinal inflammation. Thus, new simpler and cheaper tools
are required to evaluate the severity of the disease. The aim of our study was to evaluate the contribution of the neutrophil/
lymphocyte ratio (NLR) for assessing the severity of UC.
Patients and Methods:
We performed a retrospective study over a 5 year period (January 2012- December 2016), including
68 UC patients, from ambulatory or hospitalized, divided into two groups: the first group of 23 patients (33.8%) with active
disease and the second group of 45 patients (66.2%) of inactive UC. Disease activity was assessed using the Mayo score and the
data was statistically analyzed using SPSS20.
Results:
Mean age of patients was 39 years (19-78 yrs). Female-male ratio was 0.78 and the average disease duration was 8
years. Seven cases (10.3%) were diagnosed with pancolitis. Of the 23 patients with active UC, 14 patients had mild to moderate
disease and 9 patients had a severe form. In patients with inactive disease, average NLR was 2.36 (0.79 to 10.84), while in
patients with active UC average NLR was 4.28 (2.18 to 11.59) with a significant difference (p <0.01). No significant NLR
variations were observed between the patients with mild to moderate disease and those with severe forms.
Conclusion:
In our study, NLR was significantly higher in the cases of active UC. This can be a useful marker in the assessing
and follow up of the UC activity, without giving information on the disease severity.
Key words:
ulcerative colitis, neutrophils/lymhocytes
ovidiufr@yahoo.co.ukJ Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C7-083