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Volume 10
Journal of Cancer Science & Therapy
Cancer Summit 2018
July 02-03, 2018
July 02-03, 2018 Bangkok, Thailand
World Cancer Summit 2018
Clinical Features and Outcomes of Carcinoma of Unknown Primary Site: A single center experience
Suzan. A. Al-Hassanin
Clinical oncology department, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.
Background:
Carcinoma of unknown primary (CUP) is a heterogeneous entity of malignant epithelial tumors. In general, CUP
follows an aggressive biological and clinical behavior. There is generally limited information regarding this issue. Objectives:
To assess clinical and epidemiological features of patients diagnosed with CUP. Patients and method: All patients categorized
as having CUP who attended the department of clinical oncology, Menoufia University from January 2013 to December 2015
were included in the study. The patients’ features, investigations and clinical outcomes were collected. Also, time to progression
(TTP) and overall survival (OS) were calculated. Results: The study included 103 patients representing about 2.2 % of the
total number of patients visited clinical oncology department outpatients’ clinic during the same period. Most of the patients
were males, the mean age of the patients was 58 years, pain was the most common presenting symptom, and adenocarcinoma
was the most common reported pathological subtype. Only 50.5% of the patients were fit to receive platinum combination
chemotherapy. The median TTP was 2 months and the median OS was 3 months. Age, performance status & presenting
symptom had statistically significant relation with TTP. While, the baseline performance status, presenting symptoms and
pathological subtype had statistically significant relation with OS.
Conclusion:
Carcinomas of unknown primary origin are not uncommon tumors in clinical oncology department, Menoufia
University with wide varieties of clinical presentations. Baseline performance status, presenting symptoms and pathological
subtype had statistically significant relation with OS.
suzan.alhassanin@med.menofia.edu.egJ Cancer Sci Ther 2018, Volume 10
DOI: 10.4172/1948-5956-C5-136