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Volume 8
Journal of Clinical & Experimental Pathology
Pathology Summit 2018
July 02-03, 2018
July 02-03, 2018 Bangkok, Thailand
15
th
Global Experts Meeting on
Pathology and Laboratory Medicine
The total count of RBC and peripheral blood film in hemolytic anemic patients with and without
G-6PD enzyme deficiency
Razzak M
1
, Begum N
2
and Hossain M D
3
1
Dhaka National Medical College, Bangladesh
2
Bangabandhu Sheikh Mujib Medical University, Bangladesh
3
Sir Salimullah Medical College, Bangladesh
Background:
Erythrocyte G-6PD enzyme deficiency is an important cause of hemolytic anemia with consequent decrease
bilirubin and increase various types of abnormal cell- microcytic hypochromic cells, target cells, nucleated red cells, tear drop
cells, macrocytic cells, schizocytes, Heinz body, erythrocyte fragmentation, spherocytes and polychromasia.
Objective:
To assess the RBC count and peripheral blood film in erythrocyte G-6PD enzyme deficient with hemolytic anemia
in order to find their status.
Method:
The cross sectional study was carried out in the Department of Physiology, BSMMU, Dhaka from July 2008 to 2009
to observe the RBC count and peripheral blood film in patient with hemolytic anemia. For this, total number of 50 hemolytic
anemic patients (Groups-B) with age ranged from 5 to 30 years of both sexes was studied. Among them, 25 were without
G-6PD deficient hemolytic anemia (group-B1) and 25 were hemolytic anemia with G-6PD deficiency (group-B2). Age and
sex matched 30 apparently healthy subjects with normal blood G-6PD were included to observe baseline data (Group-A)
and also for comparison. The subject was selected from out-patient Department of Hematology, Bangabandhu Sheikh Mujib
Medical University, Dhaka. Blood erythrocyte G-6PD enzyme level and total RBC count were measured by standard laboratory
techniques. Analysis of data was done by unpaired student’s t-test.
Result:
The total RBC count was significantly lower Group B2 vs. Group A and also Group B1 which were statically significant.
Various types of abnormal cell were found Group B1 and also Group B2.
Conclusion:
From this study, it may be concluded that, increased hemolysis of RBC with low RBC count and various types of
abnormal cell were found in G-6PD deficient hemolytic anemic patients which might be membrane defect.
rakhi59435943@gmail.comJ Clin Exp Pathol 2018, Volume 8
DOI: 10.4172/2161-0681-C2-049