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conferenceseries
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Volume 7, Issue 5 (Suppl)
J Clin Exp Pathol
ISSN: 2161-0681 JCEP, an open access journal
Pathology Congress 2017
November 13-14, 2017
NOVEMBER 13-14, 2017 OSAKA, JAPAN
14
th
Asia Pacific Pathology Congress
Primary pulmonary myxoid sarcoma: Rare entity
Shroque Zaher
Consultant Histopathologist, UAE
T
his case represents a rare entity-primary pulmonary myxoid sarcoma, of which to the best of our knowledge only 10 other
cases have been reported in the literature. They are defined by distinctive histo-morphological features and characterized
by a recurrent fusion gene. All tumors involved pulmonary parenchyma with a predilection for the endobronchial component.
They appear to have a predilection for females, with 7 of the 10 reported cases, occurring in women. Microscopically, they are
lobulated tumors comprising cords of polygonal, spindle, stellate cells with myxoid stroma, morphologically reminiscent of
extra-skeletal myxoid chondro-sarcoma. Tumors were immune-reactive for only vimentin and weakly focal for EMA, although
our specific case was negative for these markers. In 7 of the 10 tumors, a specific
EWSR1-CREB1
fusion gene was demonstrated
by reverse transcription-polymerase chain reaction. This gene fusion has been described previously in 2 histologically and
behaviorally different sarcomas: Clear cell like sarcoma-like tumors of the gastrointestinal tract and angiomatoid fibrous
histiocytoma; however, this is a novel finding in tumors with the morphology described and occurring in the pulmonary
region.
Biography
Shroque Zaher is a Consultant Histopathologist with a specialist interest in hematopathology, pulmonary pathology and medical education. She has completed her
Pathology training at the London and East of England Deaneries and gained her CCT in 2016. She has obtained her FRCP from the Royal College of Pathologists,
United Kingdom in 2015.
drruki@hotmail.comShroque Zaher, J Clin Exp Pathol 2017, 7:5 (Suppl)
DOI: 10.4172/2161-0681-C1-040