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Volume 7, Issue 5 (Suppl)
J Clin Exp Pathol
ISSN: 2161-0681 JCEP, an open access journal
Pathology Congress 2017
November 13-14, 2017
NOVEMBER 13-14, 2017 OSAKA, JAPAN
14
th
Asia Pacific Pathology Congress
LDB2
expression in mouse hair follicles and its knock out provokes skin problem
Jonghyo Lim
Yonsei University, Republic of Korea
T
he mammalian epidermis and hair follicles are highly dynamic tissues that undergo frequent turnover and cycling.
Numerous stem cells reside in epidermis and hair follicles and they interact with a stem cell niche environment. This
interaction maintains epidermal and hair follicle proliferation and differentiation program. If these systems broke down, skin
abnormality would be occurred like severe alopecia, hyperkeratosis and skin inflammation, etc. Here, we show that
LDB2
is important for skin epidermal homeostasis and hair follicle stem cell maintenance.
LDB2
KO mouse began to show severe
alopecia phenotype about 5-week-old (P35) age. But, it recovered at 6-week-old age, but as follicle cycling goes on, severe hair
shedding occurs. This alopecia phenotype may be due to the hair follicle stem cell and epidermal keratinocyte maintenance
problem. Hair follicle stem cells are significantly reduced in
LDB2
KO mouse versus WT mouse. Moreover, epidermal
differentiation marker is irregularly expressed in
LDB2
KO mouse. Synthetically,
LDB2
that acts as a co-transcriptional factor
of various genes has a very important function in skin environment.
Biography
Jonghyo Lim is currently pursuing his graduation in Yonsei University, Republic of Korea. He has received his Bachelor’s degree in Biochemistry from Yonsei University in
2013. His research focuses on vessel development in various organs in mouse and molecular mechanisms of vessel sprouting by
in vitro
cellular work.
jhyolim@naver.comJonghyo Lim, J Clin Exp Pathol 2017, 7:5 (Suppl)
DOI: 10.4172/2161-0681-C1-041