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Volume 7, Issue 5 (Suppl)

J Clin Exp Pathol

ISSN: 2161-0681 JCEP, an open access journal

Pathology Congress 2017

November 13-14, 2017

NOVEMBER 13-14, 2017 OSAKA, JAPAN

14

th

Asia Pacific Pathology Congress

Gastro-protective potential of melatonin versus melatonin loaded niosomes on gastric ulcer healing

in rats

Ebtehal Abdelkhalik Ahmed Mohammed

1

, Nasser Anwar

2

, Omyma Galal

1

, Mahmoud El-Sabahy

1

and Mokhtar Taha

1

1

Assuit University, Egypt

2

Al-Azhar University, Egypt

T

he present study was conducted to investigate the therapeutic effects of melatonin and melatonin-loaded niosomes on

ethanol-induced gastric lesions. Morphological and biochemical changes associated with each drug were investigated.

70 apparently healthy female albino rats were randomly assigned to 4 experimental groups. The first group (induction group)

included 10 rats that were given 1 ml 70% ethanol and sacrificed after 1 and 1/2 hour. The second group (melatonin-treated

group) included 25 rats that were administrated with 2mg/rat melatonin by gastric tube daily after induction of ulcer by ethanol.

Five rats were sacrificed after 3, 7, 14, 21, and 28 days post-treatment. The third group (melatonin-loaded niosomes treated

group) consisted of 25 rats that were given melatonin-loaded niosomes in the same dose and route as the third group. Five rats

were sacrificed after 3, 7, 14, 21 and 28 days post-treatment. The fourth group is control group. Gross lesions, conventional

histological examination as well as biochemical analysis were carried out for each subgroup. Melatonin-loaded niosomes

showed early impressive gastro-protection and improved the micro-vascular damages as early as 7 days post-treatment while

unloaded melatonin therapy exerted their effects after 14 days, respectively. Biochemically, the cases of melatonin-loaded

niosomes achieved the lowest mean values of lipid peroxidation and highest mean values of total antioxidants compared

to other values recorded in case of unloaded melatonin therapy and these results are in accordance with that of the histo-

pathological findings.

Biography

Ebtehal Abdelkhalik Ahmed Mohammed has worked as Tutor at Department Animal Pathology and Clinical Pathology, College of Veterinary Medicine, Assiut

University in Egypt and has been working as an Assistant Lecturer. He is pursuing PhD at KNU Stem Cell Institute, Kangwon National University, Republic of Korea.

ebtehalabdelkhalik@aun.edu.eg

,

ebtehalabdelkhalik@ymail.com

Ebtehal Abdelkhalik Ahmed Mohammed et al., J Clin Exp Pathol 2017, 7:5 (Suppl)

DOI: 10.4172/2161-0681-C1-041