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Parkinsons 2016
December 05-07, 2016
Volume 6 Issue 6(Suppl) J Alzheimers Dis Parkinsonism
ISSN: 2161-0460 JADP, an open access journal
conferenceseries .com
December 05-07, 2016 Phoenix, USA
2nd International Conference on
Parkinson’s Disease & Movement Disorders
Hong Jiang et al., J Alzheimers Dis Parkinsonism 2016, 6:6(Suppl)
Nesfatin-1 protects dopaminergic neurons against MPTP neurotoxicity through C-Raf/ERK1/2
dependent anti-apoptotic pathway
Hong Jiang, Xiao-Li Shen, Ning Song and Jun-Xia Xie
Qingdao University, China
S ome brain-gut peptides have been reported to have a close relationship with the central dopamine system. Nesfatin-1, a
satiety brain-gut peptides co-expressed with ghrelin in X/A like endocrine cells in the gastric glands, has been reported
exerted neuroprotective efficacy in center neurons system. Here we defined the neuroprotective effects of nesfatin-1 against
MPTP-induced dopaminergic neuron degeneration in vivo and MPP+-induced cytotoxicity in vitro with its anti-apoptotic
action via ameliorating mitochondrial dysfunction by activation of C-Raf/ERK1/2 pathway. In MES23.5 dopamingernic cells,
nesfatin-1 pretreatment antagonized MPP+-induced mitochondrial dysfunction related apoptosis cascades including ΔΨm
collapse, mitochondrion Cyt C releasing, caspase-3 activation and morphological changes of nuclei. This protective effect was
abolished by selective inhibitor of C-Raf and ERK1/2. In C56BL/6 mouse, intracerebroventricular nesfatin-1 pretreatment
attenuated MPTP-induced dopaminergic neuronal degeneration in the SNpc, dopaminergic fibers depletion, dopamine and
its metabolites contents depletion in the striatum. Our data suggested nesfatin-1 had the potential to be considered as an agent
for therapy of Parkinson’s disease.
Biography
Hong Jiang has completed her PhD from Qingdao University and Post-doctoral studies from Sun Health Research Institute. She is the Vice Dean, Medical College
of Qingdao University. She has published more than 50 papers in reputed journals and has been serving as an Editorial Board Member of Current Alzheimer’s
Disease.