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Parkinsons 2016
December 05-07, 2016
Volume 6 Issue 6(Suppl) J Alzheimers Dis Parkinsonism
ISSN: 2161-0460 JADP, an open access journal
conferenceseries .com
December 05-07, 2016 Phoenix, USA
2nd International Conference on
Parkinson’s Disease & Movement Disorders
Yu Zhou et al., J Alzheimers Dis Parkinsonism 2016, 6:6(Suppl)
Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity
in the hippocampus and causes recognition memory deficits
Yu Zhou, Lin Cui, Ming Yu and Nan Li and Li Guo
Medical College of Qingdao University, China
Disrupted-in-schizophrenia 1(DISC1) is a promising candidate susceptibility gene for a spectrum of psychiatric illnesses
that share cognitive impairments in common, including schizophrenia, bipolar disorder and major depression. Here
we report that DISC1 L100P homozygous mutant shows normal anxiety- and depression-like behavior, but impaired object
recognition which is prevented by administration of atypical antipsychotic drug clozapine. Ca2+ image analysis reveals
suppression of glutamate-evoked elevation of cytoplasmic [Ca2+] in L100P hippocampal slices. L100P mutant slices exhibit
decreased excitatory synaptic transmission (sEPSCs and mEPSCs) in dentate gyrus (DG) and impaired long-term potentiation
in the CA1 region of the hippocampus. L100P mutation does not alter proteins expression of the excitatory synaptic markers,
PSD95 and synapsin-1; neither does it changes dendrites morphology of primary cultured hippocampal neurons. Our findings
suggest that the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative
information processing and contribute to recognition deficits in DISC1 L100P mutant mice.
Biography
Yu Zhou has completed her PhD from the Chinese Academy of Sciences (CAS), Shanghai Life Science Center and Postdoctoral training from Department of
Neurobiology, University of California at Los Angeles (UCLA). She is currently appointed as a Full Professor in the Medical School of Qingdao University. Her research
interests are focused on neurobiology of cognition and associated disorders. She has published more than 25 research papers in reputed neuroscience journals.