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Parkinsons 2016
December 05-07, 2016
Volume 6 Issue 6(Suppl) J Alzheimers Dis Parkinsonism
ISSN: 2161-0460 JADP, an open access journal
conferenceseries .com
December 05-07, 2016 Phoenix, USA
2nd International Conference on
Parkinson’s Disease & Movement Disorders
Rudy Capildeo, J Alzheimers Dis Parkinsonism 2016, 6:6(Suppl)
Parkinson’s disease is not a disease
Rudy Capildeo
Nuffield Hospital, UK
S ince the time of James Parkinson, we have come to recognize a medical condition characterized by the gradual appearance
of stiffness, slowness, reduced mobility, feeling old for one’s years, altered gait with stumbles, and even falls. Tremor is not
always present. Families are often aware of these changes before the patient. At no stage in this condition is there an obvious
illness. Parkinson, in his essay described just six cases. He recognized the slow progress of the condition over many years and
that the clinical signs were asymmetric. Charcot and Gower found no neuropathological changes. Gower famously said “you
do not die from Parkinson’s Disease (PD) but with it”. We recognize “Non-Motor” features of PD, the slow onset of PD over
many years and the positive response of PD to L-Dopa Therapy. PD is now considered to be a disorder of the basal ganglia
and with DAT scanning we can measure dopamine transporter uptake. Qualitative assessment of DAT scans reveals loss of the
“Comma Shape” in PD cases but quantitative measurements reveal an obvious asymmetry in early PD cases. This data will be
presented to show that PD (as opposed to Parkinsonism or PD plus syndromes) is a dopamine deficiency disorder and not a
disease.
Biography
Rudy Capildeo is a Consultant Neurologist who set up one of the first PD clinics in London, UK in 1973 at The Charing Cross Hospital, where he also organized
the first major International PD Symposium in 1979 when Sinemet Plus was first introduced by MSD. He was a Senior Investigator in the 5-year Sinemet CR First
Trial. A frequent presenter in national and international meetings, he continues his interest in PD in his work and in his role as a Teacher.