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Journal of Alzheimers Disease & Parkinsonism | ISSN: 2161-0460 | Volume: 8
October 19-20, 2018 | New York, USA
5
th
International Conference on
Parkinson’s disease and Movement Disorders
Notes:
Comparison between the efficacy of vinpocetine, pomegranate, vitamin b complex, vitamin e in
providing protection against parkinsonian syndrome induced by manganese in rats
Azza A Ali
Al-Azhar University, Egypt
Background:
Parkinson's disease (PD) is the most common neurodegenerative movement disorder characterized by
insufficient production of dopamine as well as motor and cognitive decline. Excessive exposure to Manganese (Mn) is
associated with extrapyramidal motor disorder similar to PD. Vinpocetine (Vin) has a neuroprotective effect which claimed
to enhance brain neurotransmitter concentration, glucose and oxygen consumption as well as cerebral metabolism and blood
flow. Pomegranate (POM) has been extensively referenced in medical folklore due to its dopaminergic neuroprotective effect
as well as the powerful antioxidant, anti-inflammatory and antiapoptotic activity. Vitamin B (Vit B) complex also has ability to
improve brain blood circulation and promote neurotransmitters synthesis, while Vitamin E (Vit E) has a neuroprotective effect
by scavenging free radicals and preventing neuronal damage
Objective:
To compare between the impact of Vin, POM, Vit B complex, Vit E and their combinations against parkinsonian
syndrome induced by Mn in rats.
Methods:
Rats received daily for 4 weeks; Saline for normal group or MnCl2 (10mg/kg IP) either alone for control PD model
or in combination with Vin (20mg/kg PO), POM (150mg/kg PO), Vit B Complex (8.5mg/kg PO), Vitamin E (100mg/kg PO) or
their combinations. Behavioral tests as Grid, Bar, Swimming, Open-field and Y-maze were used. In addition to histopathological
examinations, biochemical examinations for brain monoamines, AChE, BDNF, GSK-3, Glutamate, GABA, INOS, Cox2 as well
as for neuroinflammatory, apoptotic and oxidative markers were also evaluated.
Results:
All used treatments especially Vin and POM improvedmotor, memory and cognitive decline induced byMn. However,
combination of treatments showed more pronounced improvements as indicated by the increase in monoamines, BDNF and
Glutamate together with the decrease in AChE, GSK-3, GABA, neuroinflammatory, apoptotic and oxidative stress markers
(MDA, NO, INOS). These results were highly confirmed by histopathological examination.
Conclusion:
Neuronal degeneration as well as behavioral changes induced by Mn was partially improved by each of Vin, POM,
Vit B complex or Vit E with more advantages to Vin and POM but their combination showed more pronounced protection
from Parkinsonian syndrome induced by Mn than the solo treatment.
Biography
Azza A Ali has completed her PhD specialized in Pharmacology and Toxicology from Faculty of Pharmacy, Cairo University, Egypt. Her postdoctoral studies
included different scientific aspects especially on neurodegenerative disorders; she also developed research line of behavioral pharmacology in Egypt. She is
member of many scientific societies as (AAPS) and Alzheimer's Association (ISTAART). She is also Editorial Board Member of many international Journals as Brain
Disorder & Therapy, Acta Psychopathologica, EC Pharmacology and Toxicology as well as Organizing Committee Member and Chairperson at many international
Conferences as the International Conference on Brain Disorders & Dementia Care, Canada (2017) and International Conference on Parkinsons Disease &
Movement Disorders, USA (2017). She published more than 60 papers in reputed journals, supervised and discussed more than 90 PhD and MSc thesis and
actively participated by oral and posters presentations at many international conferences especially on Alzheimer's disease and Dementia as well as on Parkinsons
disease as Dementia Conferences (2015, 2016), Alzheimer's Association International Conference (AAIC 2016, 2017) and Parkinsons Conference (2017). She has
many appreciation certificates and certificate of best presentation award at 19th International Conference on Environmental Pollution and Pollution Control, London,
UK (ICEPPC 2017). Now she is a Head of Pharmacology and Toxicology Department at Al-Azhar University, Egypt.
azzamoro@gmail.comAzza A Ali, J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C6-052