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Journal of Alzheimers Disease & Parkinsonism | ISSN: 2161-0460 | Volume: 8
October 19-20, 2018 | New York, USA
5
th
International Conference on
Parkinson’s disease and Movement Disorders
Antioxidant and inhibitory activity towards acetylcholinesterase and adenosine deaminase of essential oils
from Nigeria ginger (
Zingiber officinale
) and turmeric (
Curcuma longa
) rhizomes
Ayodele Jacob Akinyemi
Afe Babalola University, Nigeria
S
tudies have shown that neuroinflammatory processes play an important role in the pathogenesis of neurological disorders.
Therefore, plant foods with anti-inflammatory potential could be used to slow the progression of these diseases. Hence, the
present study sought to investigate the effect of essential oils from Nigeria ginger and turmeric rhizomes on some inflammatory
biomarkers (IL-6, IL-10, and TNF-Alpha) as well as acetylcholinesterase (AChE) and adenosine deaminase (ADA) activities (key
enzymes associated with neurodegeneration) in cadmium-induced neuroinflammation in rats. The result revealed that essential oil
from ginger and turmeric rhizomes exert an immunomodulatory effect by preventing alterations of some cytokines (IL-6, IL-10, and
TNF-Alpha) levels in Cd-treated rats. In addition, the essential oils inhibited hippocampus and pre-frontal cortex AChE and ADA
activities in Cd-treated rats. In conclusion, essential oil from ginger and turmeric rhizomes could be harness as anti-inflammatory
drugs/supplements for the management/prevention of neurodegenerative diseases associated with inflammation.
ajakinyemi2010@yahoo.co.ukJ Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C6-052