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conferenceseries.com
September 25-26, 2017 Chicago, USA
3rd International Conference on
Parkinson’s disease and Movement Disorders
Volume 7, Issue 5 (Suppl) J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460 Parkinson 2017
September 25-26, 2017
Synthetic steps towards reversible chalcogen-based sensing of essential neurodegenerative disease
factors
Tesla Yudhistira1, Sandip V Mulay1,2, Youngsam Kim1,2 and David G Churchill1,2
1Korea Advanced Institute of Science and Technology, Korea
2Institute for Basic Science, Korea
3Indonesia Endownment Fund for Education, Indonesia
The chemical etiology of Parkinson’s disease, among other neurodegenerative diseases, is multifactorial and relates to
proteins, biomolecules, as well as small soluble analytes including metal ions and ROS. The over-abundance of ROS/
RNS could be an indication of Alzheimer’s and Parkinson’s disease (PD). Recent articles by us and other researchers have
begun connecting the dots of this small molecule chemistry. There is incredible interest in preparing next-generation (e.g.
ROS) probes that are reversible, sensitive, and also robust. Concentrations and the innate chemistry of selenium connect
to proposed/tentative etiology of Parkinson’s disease. For all of these reasons and more, we feel that the pursuit of studying
organo-selenium chemistry in the context of PD will be fruitful in years to come. In this oral presentation and discussion,
selenium, a key element in the redox chemistry of life and for its ability to engage in catalysis, is presented and debated in terms
of diagnosis (probing) as well as potentially in therapy. To-date, the role of fluorescence and fluorescent molecules in diagnosis,
treatment, as well as in biomedical research, has great current medicinal significance; this is the focus of concentrated effort
across the scientific research spectrum. In particular, organo-selenium and/or organo-sulfur molecules show great promise
in the detection of reactive oxygen/nitrogen species (ROS/RNS)-key factors in ageing/neurodegenerative disease in living
systems. The boron dipyrromethene (BODIPY) system is a versatile class of fluorescent dye; it is commonly used in labeling,
chemosensing, light-harvesting, and solar cell applications due to the many compelling characteristics, including an intense
absorption profile, a sharp fluorescence emission spectrum, and high fluorescence quantum yield. As part of our ongoing
effort to study chalcogenide systems, dithiomaleimide- and phenyl selenide probes (among many others) have been designed,
synthesized and characterized. Commonly, fluorescence is quenched by photoinduced electron transfer (PeT) mechanism.
These probes show a turn-on fluorescence response upon reaction with ONOO- (BDP-NGM) and HOCl (Mes-BOD-SePh)
with significant increase in emission intensity with fast response to ROS/RNS. Live cell imaging showed that the current probes
can be used for the selective detection of ROS and RNS in living systems. Time- permitting, we also like to briefly showcase
other recent related fluorescent probes and studies.
Biography
Tesla Yudhistira is eagerly studying for his PhD in the Department of Chemistry at the Korea Advanced Institute of Science and Technology (KAIST) under
the supervision of Prof. David G Churchill. He has obtained a bachelor’s degree in Chemistry from the University of Indonesia. While pursuing science as an
undergraduate, he worked in the bio electrochemistry laboratory as a student Researcher.
Tesla Yudhistira et al., J Alzheimers Dis Parkinsonism 2017, 7:5 (Suppl)
DOI: 10.4172/2161-0460-C1-030