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conferenceseries.com
September 25-26, 2017 Chicago, USA
3rd International Conference on
Parkinson’s disease and Movement Disorders
Volume 7, Issue 5 (Suppl) J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460 Parkinson 2017
September 25-26, 2017
Reprogramming and programming of human hindbrain cells
Jianfeng Lu
Tongji University, China
Human induced pluripotent stem cells (iPSCs) are derived from somatic cells, such as skin fibroblasts, which keep the whole
set of disease genome and could mimic the genetic environment. Without high efficiency of motor neuron differentiation
from human iPSCs, it is hard to model motor neuron diseases in a dish using human iPSCs. By the development of a method
for efficient conversion human iPSCs into motor neurons, we have successfully modeled motor neuron diseases, such as spinal
muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) in vitro. This will help us understand motor neuron diseases
deeply and help the development of effective treatment for the diseases.
Biography
Jianfeng Lu is a professor working in Tongji University, Shanghai, China. He has been working in the field of pluripotent stem cells and neuroscience for more than
12 years. By modulating signaling pathways, he and his colleagues are now able to efficiently convert human pluripotent stem cells into different subtypes of neural
cells, which offer very useful tools for modeling diseases, for screening drugs and for cell therapy.
Jianfeng Lu, J Alzheimers Dis Parkinsonism 2017, 7:5 (Suppl)
DOI: 10.4172/2161-0460-C1-030