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Pancreatic Disorders & Therapy | ISSN: 2165-7092 | Volume 8
Hepatobiliary & Pancreatic Disorders
3
rd
International Conference on
September 17-18, 2018 | Philadelphia, USA
Electrochemotherapy in locally advanced pancreatic cancer: Preliminary results of a phase I/II study
Francesco Izzo
National Cancer Institute of Naples, Italy
Objective:
Report the preliminary results on electrochemotherapy (ECT) in the treatment of locally advanced pancreatic cancer of
a phase I/II study and described the new functional imaging tools to assess ECT response in Magnetic Resonance (MR) imaging
compared to morphological Computer Tomography (CT), ultrasound (US) without and with contrast enhancement (CEUS) and MR
Imaging.
Materials and Methods
: Thirteen patients were enrolled in an ongoing clinical phase I/II study approved by the Ethical Committee
of National Cancer Institute G. Pascale Foundation - IRCCS of Naples. ECT with bleomycin was performed during open surgery.
All patients underwent the US and CT scan, before and after ECT treatment; 7 patients were evaluated using morphological and
functional (dynamic contrast enhancement-DCE and diffusion-weighted- DW) parameters in MR; 5 patients underwent CEUS.
RECIST criteria were used to evaluate ECT response on US, CT and MR images. Functional parameters were also used to evaluate
ECT response on MR images.
Results:
No acute (intraoperative) and/or postoperative serious adverse events related to electrochemotherapy were observed; no
clinically significant electrocardiographic, hemodynamic, or serum biologic changes were noted. No clinically relevant elevation of
amylase or lipase levels was observed and no bleeding or damage to surrounding viscera occurred. In three patients had seen splenic
infarction without thrombosis of the splenic vessels.
Conclusion:
Electrochemotherapy is a feasible and safe treatment modality in patients with locally advanced pancreatic
adenocarcinoma. Dynamic and diffusion MR imaging in comparison to MR morphological sequence alone and to UC and CT
imaging is more suitable to assess ECT treatment response.
f.izzo@istitutotumori.na.itPancreat Disord Ther 2018, Volume 8
DOI: 10.4172/2165-7092-C1-012