10 / 13
Page 52
Notes:
Pancreatic Disorders & Therapy | ISSN: 2165-7092 | Volume 8
Hepatobiliary & Pancreatic Disorders
3
rd
International Conference on
September 17-18, 2018 | Philadelphia, USA
Outcomes of chronic hepatitis B in a primary care setting
Khitam A AlOdhaibi, Abdullah Alkhenizan
and
Patricia McWalter
King Faisal Specialist Hospital & Research Center, Saudi Arabia
Background:
Although HBV infection is decreasing because of the implementation of HBV vaccination, chronic HBV is still
one of the most predominant hepatitis. Chronic infection of HBV is one of the leading causes of cirrhosis, decompensated liver,
hepatocellular carcinoma (HCC) and liver-related death. This is the first national study to evaluate the long-term outcomes of chronic
HBV infection in a primary care setting.
Materials and methods:
This is a retrospective cohort study. Data were collected retrospectively from the medical records of all
patients who were diagnosed with hepatitis B and were seen in the Department of Family Medicine at KFSH&RC from January
2002 to March 2017. Data collection included hepatitis B serology, hepatitis B Detection and Quantitation, liver function test, liver
ultrasound results, liver biopsy results and rates of HCC, cirrhosis and mortality.
Results:
We found 50 patients diagnosed with hepatitis B. The mean age of included patients was 50 years with 72% male and 28 %
female. The majority of our population were Saudi (90%). Among the included patients, (20%) have chronic hepatitis, while (80%)
became chronic carriers. Genotype was done for 14% of included patients, genotype D (12%) was the predominant genotype followed
by E (2%). Elevated liver enzymes were observed in (60%) of our population, liver cirrhosis developed in (16%), while (4%) of them
developed HCC. The death occurred in (2%) of patients with non-liver related causes.
Conclusion:
The prevalence of hepatitis B is dropping in our community. Our study showed that the majority of patients with chronic
HBV became chronic carriers. Progression to Liver cirrhosis was modest and the development of HCC was relatively rare. Liver-
related mortality rate was low.
kalodhaibi@kfshrc.edu.saPancreat Disord Ther 2018, Volume 8
DOI: 10.4172/2165-7092-C1-012