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Pancreatic Disorders & Therapy | ISSN: 2165-7092 | Volume 8
Hepatobiliary & Pancreatic Disorders
3
rd
International Conference on
September 17-18, 2018 | Philadelphia, USA
Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant
behavior of pancreatic ductal adenocarcinoma
Dong Tang
Clinical Medical College of Yangzhou University, China
P
ancreatic ductal adenocarcinoma (PDAC) is one of the most common malignant tumors with poor prognosis due to extremely
high malignancy, low rate of eligibility for surgical resection and chemoradiation resistance. Increasing evidence indicates that
the interaction between activated pancreatic stellate cells (PSCs) and PDAC cells plays an important role in the development of
PDAC. By producing high levels of cytokines, chemotactic factors, growth factors and excessive extracellular matrix (ECM), PSCs
create desmoplasia and a hypoxic microenvironment that promote the initiation, development, evasion of immune surveillance,
invasion, metastasis and resistance to chemoradiation of PDAC. Therefore, targeting the interaction between PSCs and PDAC
cells may represent a novel therapeutic approach to advanced PDAC, especially therapies that target PSCs of the pancreatic tumor
microenvironment.
83392785@qq.comPancreat Disord Ther 2018, Volume 8
DOI: 10.4172/2165-7092-C1-012