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conferenceseries
.com
Volume 7
Journal of Pain & Relief
ISSN: 2167-0846
Pain Management 2018
October 11-12, 2018
October 11-12, 2018 | Zurich, Switzerland
7
th
International Conference and Exhibition on
Pain Research and Management
Antipyretic activity of ethnomedicinal plant
Hydrocotyle javanica
Krithika N
Presidency College, India
Statement of the Problem
: Fever or pyrexia is an elevation of body temperature that exceeds the normal daily variation and
occurs in conjunction with an increase in the hypothalamic set point from 37˚C to 39˚C. The objectives in treating fever are
first to reduce the elevated hypothalamic set point and second to facilitate heat loss. A trigger of the fever causes a release of
prostaglandin E2 (PGE2). Antipyretic property of medicinal plants can be assumed to be mediated through interference of
prostaglandin synthesis and inhibition of cytokines release. The present study was proposed to assess the antipyretic activities
of ethnomedicinal plant
Hydrocotyle javanica
Thunb. (Apiaceae) on Wistar albino rats
Methodology & Theoretical Orientation
: Brewer’s yeast (sub-cutaneous injection of 20% aqueous suspension of dried yeast
in 2% gum acacia at a dose of 20 ml/kg below the nape of the neck) was used to induce pyrexia in the all experimental rats after
measuring their initial rectal temperatures. The test animals were then divided into five groups. Group I was the control and,
group II was administered the reference drug paracetamol. Group III, IV and V rats were administered the plant extract of
dosage 150, 300 and 450 mg/kg of body weight respectively. Rectal temperatures of the test rats were recorded after 18 hrs. Of
inducing pyrexia for every one hour up to 23 hours, against the standard reference drug paracetamol
Findings
: The whole plant methanol extract of
H. javanica
(300 and 450 mg/kg b. wt.) significantly attenuated hyperthermia in
test rats in 1 hr. observation (
p
<0.01) and was even more significant (
p
<0.001) from 2-6 hrs. Observation period in comparison
to control. The brewer’s yeast elevated the body temperature in the rats to 39.38±0.16°C after 24 hrs., which was brought down
to 36.12±0.16°C in 3 hrs. after treatment with 150 mg/kg of
H. javanica
extract. Whereas the other doses 300 and 450 mg/kg
of
H. javanica
plant extract reduced the elevated body temperature to 36.54±0.24˚C and 36.72±0.56˚C respectively after 2 hr.
Conclusion & Significance
:
Hydrocotyle javanica
evinced a significant antipyretic effect in yeast-provoked elevation of body
temperature in experimental rats, and its effect is comparable to that of paracetamol. The investigated plant
Hydrocotyle javanica
is a febrifuge and could be recommended as a potent antipyrexia agent/ source of phytotherapeutic ingredient.
Recent Publications:
1. Dinarello C A and Porat R (2008) Fever and Hyperthermia. In: Harrison’s Principle of Internal medicine, 17th ed. The
McGraw-Hill companies Inc. USA, 104, ISBN 978-0-07174889-6
2. Sharma J P, Srivastava A, Thakur S P, Barpete P K and Singh S (2010) Herbal medicine as antipyretic: A comprehensive
review. International Journal of Pharmacy & Life Sciences 1:18-22.
3. Tomazetti J, Avila D S, Ferreira A P et al. (2005) Baker yeast induced fever in young rats: characterization and validation
of an animal model for antipyretics screening. Journal of Neuroscience Methods 147:29–35.
4. Pasin J S M, Ferreira A P O, Saraiva A L L et al.(2010) Diacerein decreases TNF- and IL-1 levels in peritoneal fluid and
prevents Baker’s yeast-induced fever in young rats. Inflammation Research 59:189–96.
5. VealeWL, Cooper K E, and PittmanQ J (1977) Role of prostaglandins in fever and temperature regulation. In: P Ramwell
(ed.). The Prostaglandins, New York, USA, Springer, 145-67, ISBN: 978-1-4615-8055-3.
Krithika N, J Pain Relief 2018, Volume 7
DOI: 10.4172/2167-0846-C1-020