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conferenceseries
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Volume 6, Issue 5 (Suppl)
J Pain Relief, an open access journal
ISSN: 2167-0846
Pain Management 2017
October 05-06, 2017
5
th
International Conference and Exhibition on
October 05-06, 2017 London, UK
Pain Research And Management
Mechanisms underlying alcohol withdrawal-induced pain chronification after surgery
Feng Tao
1
, Sufang Liu
1
, Zhiying Zhao
1
, Yan Guo
2
, Hui Shu
1
and
Xiudong Yang
1
1
Texas A&M University, USA
2
The First Hospital of Shanxi Medical University, China
C
hronic postsurgical pain is a serious health issue in clinical practice; however, it is unclear how acute to chronic postsurgical
pain transition occurs. Previous studies have demonstrated that chronic ethanol consumption shares overlapping neural
substrates with pain transmission. It has also been reported that ethanol exposure and withdrawal can regulate α-amino-3-
hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor activities, which are involved in the pathogenesis of postsurgical
pain. In the present study, we investigated the effect of ethanol withdrawal on plantar incision-induced postsurgical pain.
C57BL/6 male mice (8-10 weeks) were given unlimited access to drink different concentrations of ethanol for four weeks, and
next day following 4-week ethanol administration, a 5-mm longitudinal plantar incision was made in the left hind paw of the
mice. We found that withdrawal from 4-week ethanol consumption greatly prolonged plantar incision-induced mechanical
pain, but ethanol withdrawal alone did not produce pain behaviors. We also found that ethanol withdrawal markedly enhanced
plantar incision-induced AMPA receptor GluA1 phosphorylation in the spinal cord. Interestingly, targeted mutation of GluA1
phosphorylation significantly inhibited ethanol withdrawal-induced prolongation of incisional pain. In addition, we observed
that ethanol exposure increased AMPA receptor GluA2 dynamic internalization in the cultured spinal dorsal horn neurons.
As we know, AMPA receptor phosphorylation and trafficking contribute to spinal central sensitization through lowering the
threshold for long-term potentiation induction and increasing the probability of synaptic plasticity. Therefore, our results
suggest withdrawal from chronic alcohol consumption may induce the development of chronic postsurgical pain by regulating
AMPA receptor phosphorylation and trafficking in the spinal cord.
Biography
Feng Tao is an Associate Professor in the Department of Biomedical Sciences at Texas A&M University College of Dentistry. He received his R01 award and
Independent Scientist Award from NIH in 2012 and 2014, respectively. He has published more than 30 papers in peer-reviewed professional journals and he is
serving as an Editorial Board Member for some professional journals.
tao@tamhsc.eduFeng Tao et al., J Pain Relief 2017, 6:5(Suppl)
DOI: 10.4172/2167-0846-C1-014