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conferenceseries
.com
Volume 6, Issue 5 (Suppl)
J Pain Relief, an open access journal
ISSN: 2167-0846
Pain Management 2017
October 05-06, 2017
5
th
International Conference and Exhibition on
October 05-06, 2017 London, UK
Pain Research And Management
Antinociceptive activity of ethnomedicinal plant
Hydrocotyle javanica
Krithika N
1
and
Arumugasamy K
2
1
Quaid-e-Millath Government College for Women, India
2
Kongunadu Arts and Science College, India
Statement of the Problem:
The pain sensory system protects the body and maintains homeostasis by detection, localization
and identification of tissue damaging process. NSAIDS or non-steroidal anti-inflammatory drugs and opioid drugs are the
two main classes of pain relievers that come with side effects such as gastric irritation. Today, the search for a drug without
these side effects leads to a promising track of herbal medicines or herbal drugs.
Hydrocotyle javanica
Thunb. (Apiaceae) is an
ethnomedicinal herb of the southern Western Ghats. The natives use it in treatment of asthma, nervous problem, toothache
and few more. But still many other pharmacological potentials remain unexplored. The control of infections demands a drug
with efficacy but without any side effects.
Methodology &Theoretical Orientation:
This study has been attempted to elucidate the antinociceptive activity of this plant
by Eddy’s hot plate and heat conduction methods. An extensive literature survey depicted the medicinal uses of the present
plant.
Findings:
The methanol extract of the whole plant showed a significant effect in alleviating nociception in rat experimental
models. In the Eddy hot plate method, the intensity of the analgesic effect of
H. javanica
was greater than that of standard drug
indomethacin (9.18±0.136) and control (2.80±0.314) with a maximum (12.16±0.281) in the 450
mg.kg-1 dosage whereas in
the Heat Conduction Method animals treated with plant methanol extract evinced significant increase in the tail flick latency
compared to control (1.906) with a maximum (9.926±0.316) in the 450
mg.kg-1 dosage. Analgesic activity in both methods
showed a dose dependent response by the experimental rat models.
Conclusion & Significance:
H. javanica
can be used as a novel therapeutic herbal ingredient in the future that has the potential
to relieve mankind from pain and such associated diseases. Further studies on its molecular mechanism are warranted.
Biography
Krithika N is a Faculty of Botany pursuing her PhD in the field of Medico-Botany under Prof. Arumugasamy. She is currently a full-time Research Scholar under the
12th plan of University Grants Commission, Faculty Development Programme, SERO, Hyderabad, India. Her in-depth knowledge in Botany especially, medicinal
plants has helped in assessing the pharmacological aspects of an ethnomedicinal plant used by natives of Nilgiris, Tamilnadu, India. She has based her study with
reference to
Hydrocotyle asiatica (Centella)
of family Apiaceae on which enormous studies have been reported. This is a first study on her chosen plant
Hydrocotyle
javanica
Thunb.
krithikadharma@hotmail.comKrithika N et al., J Pain Relief 2017, 6:5(Suppl)
DOI: 10.4172/2167-0846-C1-014
Figure 1:
Probable mechanism of action of H. javanica methanol extract as an antinociceptive