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Volume 4, Issue 4 (Suppl)

J Laser Opt Photonics, an open access journal

ISSN: 2469-410X

Optics 2017

November 15-17, 2017

November 15-17, 2017 | Las Vegas, USA

International Conference and Exhibition on

Lasers, Optics & Photonics

PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic

therapy on cancer cells

Wei Deng, Zofia Kautzka, Wenjie Chen

and

Ewa Goldys

Macquarie University, Australia

LGA nanocomposites were developed by incorporating a photosensitizer, verteporfin and gold nanoparticles into this polymeric

matrix and utilised for enhanced photoynamic therapy on cancer cells. Both enhanced fluorescence and

generation from

verteporfin were observed in this new formulation under both 425 nm LED and 405 nm laser illumination. Amaximum enhancement

factor of 2.5 for fluorescence and 1.84 for

generation was obtained when the molar ratio of gold: VP was 5:1 and excited at

425 nm, compared with PLGA doped with verteporfin alone. The experiment results could be explained by the local electric field

enhancement of gold nanoparticles. Furthermore, improved therapeutic efficacy in human pancreatic cancer cells, PANC-1, was also

demonstrated by using this new formulation following light exposure, indicating the utility of these nanocomposites in enhanced

photodynamic therapy.

Biography

Wei Deng received her PhD degree in Chemistry with Nanotechnology background at Macquarie University, Australia in 2012. She was rewarded with a highly competitive

Fellowship (Discovery Early Career Research Award) from the Australian Research Council in 2012. She is now a Research Fellow at the Centre of Excellence in Na-

noscale Biophotonics, Macquarie University. Her research fields are mainly focused on biomedical applications of liposomes and polymer nanoparticles, in particular, light

(or X-ray)-controlled drug/gene delivery systems in cancer treatments.

wei.deng@mq.edu.au

Wei Deng et al., J Laser Opt Photonics 2017, 4:4 (Suppl)

DOI: 10.4172/2469-410X-C1-017