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Volume 6, Issue 4(Suppl) J Obes Weight Loss Ther
ISSN: 2165-7904 JOWT, an open access journal
Page 34
Notes:
Obesity Congress 2016
August 08-10, 2016
conferenceseries.com
August 08-10, 2016 Toronto, Canada
6th World Congress on
Obesity
Fructooligosacchairde (Fos) can modulate gut satietogenic hormones, gut flora and induce weight loss
in obese adults
Aparna Assudani and Mini Sheth
Maharaja Sayajirao University of Baroda, India
In India, the era of health transition has brought the dual burden of under and over-nutrition. Recent researches focuses on
identifying unconventional mechanisms of obesity involving gut - brain axis, prevention and treatment of obesity. Hence this
study was conducted with an objective to examine the effects of Fructooligosaccharide (FOS) supplementation on gut satietogenic
hormones (GLP-1, GIP, PYY, Leptin, Ghrelin and Insulin), gut-flora (Bifidobacterium, Lactobacillus, Clostridium and Bacteroides),
and anthropometric measurements. A randomized, double-blind, placebo controlled trial with 120 young obese grade –I subjects
(25-35 yrs) was designed. They were randomly assigned to groups that received either 20g FOS/d or 20g dextrose/d for 90 days.
Anthropometric measurements, fasting plasma and faecal samples were collected at baseline and post intervention. Plasma samples
for gut hormones were analyzed using Luminex x-MAP technology in sub sample of 60 subjects. Results in experimental group
revealed significant reduction in weight, BMI, WC, WHR and body fat by 2.55%, 2.45%, 2.51%, 3.11%, and 5.93% respectively
as compared to placebo group. Colonization of (8.13%) and Lactobacillus (10.77%) was significantly increased,
however significant reduction in colonization of Clostridium (1.87%) and Bacteroides (13.07%) was observed. Significant increase in
plasma level of gut satietogenic hormone GLP-1 (1.53%) and Ghrelin (17.33%) along-with reduction in Leptin (5.78%) and Insulin
(5.83%) was also observed. Weight negatively correlated (p<0.001) with GLP-1(r = -0.729) and GIP (r = -0.603) and positively with
Clostridium (r = 0.09, NS) and Bacteroides (r = 0.09, NS). Stepwise linear regression depicted GLP-1 as a strong predictor of obesity
(58.6%). Hence, FOS proves to be a promising supplement in inducing weight loss by modulating gut satietogenic hormones and
gutflora.
Biography
Aparna Assudani is currently pursuing her PhD from India in the field of Prebiotics and Obesity (Clinical Dietetics). She has 11 years of experience as a Senior Clinical
Dietitian in corporate hospitals of India. She was a part of Senior Management and member of CEO’s working committee in Apollo Hospital International Ltd. in India. She
has won 3 awards in oral and poster presentation in National Conferences conducted in India (Golden jubilee award as practicing Dietitan and Swarna padak award for
Experimental Nutrition). She has published 6 papers in reputed journals. She has recently immigrated to Canada and is looking forward for a bright career in the field of
Research and Dietetics.
Aparna Assudani et al., J Obes Weight Loss Ther 2016, 6:4(Suppl)