nutri-food-chemistry-euro-obesity-2018-posters

8 / 37

Page 86
Notes:
conferenceseries.com
Volume 8 Journal of Nutrition & Food Sciences
ISSN: 2155-9600 Nutri-Food Chemistry
&
Euro Obesity 2018
September 13-15, 2018
JOINT EVENT
September 13-15, 2018 | London, UK
14th Euro Obesity and Endocrinology Congress
&
17th World Congress on Nutrition and Food Chemistry
The effect of anti-appetite agent is dependent on various habituated foods
Sun Shin Yi1, Hye Kyung Baek1, Kwang-Ho Kim1, Hyunmook Lim1, Haesung Yang1, Bokyeong Ko1 and Hyung Seok Seo 2
Supported by National Research Foundation of Korea
NRF-2018R1D1A3B07047960
Soonchunhyang University, Republic of Korea
Over the several decades, increasing attention has been paid to the roles and regulatory mechanisms of pharmacological
agents in the treatment of obesity. Many anorectic agents such as dl-fenfluramine can lead to substantial reduction in
body weight. However, the effects of these anorectic and body weight-reducing agents are not uncommon and/or rebound
weight gain may be observed following drug withdrawal. Moreover, dl-fenfluramine intake has showed anorectic property
and weight-reducing effects are faded away in both human and experimental animals chronically medicated. In the present
study, we performed several experiments that normal diet food and western diet, respectively habituated rats for a month each,
and gave free options for food choices—both foods at the same time with dl-fenfluramine administration chronically—to
investigate whether the reasons of pharmacologic tolerance problems of chronic systemic dl-fenfluramine administrations
originate from long habituated food and/or specific food preference for taste and nutrient. In summary, dl-fenfluramine
has known its pharmacologic effect disappeared by chronic treatments, however, its anti-appetite effect can be different by
habituated foods. Therefore, we’d like to insist that the habituation or preference for specific nutrition and ingredient ratios of
various foods in the obese patients can be very important to anticipate anti-obesity drugs’ pharmacological success or failure
before showing their tolerance according to the dl-fenfluramine results.
Biography
Sun Shin Yi has completed his PhD from Seoul National University, South Korea and Post-doctorate from Marquette University, WI, USA. Now, he is a Professor
in the Department of Biomedical Laboratory Science, and an Associate Dean of Special Affairs for Planning and Chair of IACUC in the Soonchunhyang University.
He has published more than 60 papers in reputed journals and a Board Member of Korea Mouse Phenotyping Center (KMPC).
Sun Shin Yi et al., J Nutr Food Sci 2018, Volume 8
DOI: 10.4172/2155-9600-C7-072