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conferenceseries.com
Volume 8 Journal of Nutrition & Food Sciences
ISSN: 2155-9600 Nutri-Food Chemistry
&
Euro Obesity 2018
September 13-15, 2018
JOINT EVENT
September 13-15, 2018 | London, UK
14th Euro Obesity and Endocrinology Congress
&
17th World Congress on Nutrition and Food Chemistry
Evaluation of effect of vitamin D supplementation on serumAMH in vitamin D deficient PCOS women
Swati Sharma
Vivekananda Polyclinic and Institute of Medical Sciences, India
Context: PCOS is characterized by oligo or anovulation, clinical or biochemical hyperandrogenemia, and/or polycystic ovaries
on ultrasonography. Vitamin D plays a role in ovulation in PCOS.
Objective: To correlate vitamin D levels with serum AMH after vitamin D supplementation in vitamin D deficient PCOS
women.
Materials & Methods: The study design used was observational, comparative and interventional. All consenting females
diagnosed with PCOS according to Rotterdam criteria in the age group of 16–40 years were recruited. A total of 630 incident
cases of PCOS were enrolled after considering inclusion and exclusion criteria. Out of this, 30 patients each without (Group
1) and with vitamin D deficiency (Group 2) were selected using purposive sampling design to study the impact of vitamin D
deficiency on serum AMH levels. In the intervention group, 60,000 IU, once weekly vitamin D supplementation, was done for
eight weeks. After eight weeks, vitamin D and serum AMH levels were reassessed. Data was analyzed using Statistical Package
for Social Sciences Version 21.0. PCOS women having vitamin D (25OHD) levels (<20 ng/ml) were given oral vitamin D3:
60,000 IU once weekly for eight weeks. The main outcome measures were change in AMH concentration after vitamin D3
supplementation. The targeted AMH concentration was <4 ng/ml.
Results: InGroup 1, 23.3%women had AMH levels <4 ng/ml, whereas it was 20.0% inGroup 2.The correlation between vitamin
D and AMH levels was weak and not significant statistically (=0.090; p=0.495). On evaluating this correlation separately in
Groups 1 and 2, it was found to be weak but statistically not significant (=0.129; p=0.497) in Group 1; whereas, in Group 2 it
was found to be mildly positively correlated yet statistically not significant (=0.344; p=0.063). Following intervention, mean
vitamin D levels changed from 12.53±4.32 ng/ml to 33.59±8.75 ng/ml, thus showing a significant change. Vitamin D levels
were normalized (>20 ng/ml) in all the women. A statistically significant change in AMH levels was observed with mean
values changing from 4.88±2.06 ng/ml to 3.79±2.00 ng/ml. The proportion of women with normalized AMH levels (<4 ng/ml)
increased from 20% to 80% following intervention. In the vitamin D deficient group, following intervention, the correlation
between vitamin D and AMH levels was weak and not significant statistically.
Conclusion: Vitamin D levels have a regularizing effect on ovarian reserves among PCOS patients with vitamin D deficiency.
J Nutr Food Sci 2018, Volume 8
DOI: 10.4172/2155-9600-C7-072