nutri-food-chemistry-euro-obesity-2018-posters

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Volume 8

Journal of Nutrition & Food Sciences

ISSN: 2155-9600

Nutri-Food Chemistry

Euro Obesity 2018

September 13-15, 2018

JOINT EVENT

September 13-15, 2018 | London, UK

Euro

Obesity and Endocrinology Congress

World Congress on

Nutrition and Food Chemistry

Omega-3 fatty acids andmalignant ventricular arrhythmias in patients with implantable cardioverter

defibrillator

Sabrina Zeghichi Hamri

University of Bejaia, Algeria

Background & Aim:

Studies that evaluated the effects of omega-3 polyunsaturated fatty acids (n-3) on cardiovascular diseases

have yielded conflicting results. We aimed at examining the association between plant/marine n-3 and malignant ventricular

arrhythmias (MVA) among patients benefiting from the best preventive strategy including Implantable Cardioverter

Defibrillator(ICD).

Methods & Results:

Consecutive patients in whom an ICD was implanted for primary or secondary prevention of MVA were

eligible. All patients had blood fatty acid analysis. The method of Kaplan-Meier was used to estimate the survival curves in each

quartile of the main plant (ALA) and marine (EPA and DHA) n-3. Among the 238 enrolled patients, 100 had a relevant end

point recorded by the ICD or died from a cardiac cause during a mean follow up of 30±12 months. No significant difference

in MVA was observed between quartiles of ALA (log-rank test p=0.88), EPA (log-rank test p=0.58) and DHA (log-rank test

p=0.97). In a multivariate Cox proportional hazard model including age, sex, ischemic heart disease, diabetes, smoking,

hypertension and high cholesterol as covariates, we found no association between MVA and n-3: hazard ratio was 1.12 (95%

CI 0.62-2.02) for ALA and 1.44 (95% CI 0.81-2.58) for the sum of main marine n-3.

Conclusions:

Plant and marine n-3 do not seem to either increase or decrease the risk of MVA in patients who are not n-3

deficient and benefit from the most effective preventive treatment. Further studies are required to test whether n-3 deficient

patients would still benefit from n-3 supplements. Finally, these data raise major questions regarding interactions between

dietary n-3 and certain medications.

J Nutr Food Sci 2018, Volume 8

DOI: 10.4172/2155-9600-C7-072