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conferenceseries
.com
Volume 8, Issue 2 (Suppl)
J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal
Neurology 2017
March 27-29, 2017
March 27-29, 2017 Madrid, Spain
11
th
World Congress on
Neurology and Therapeutics
Vivian Hsu, J Neurol Neurophysiol 2017, 8:2 (Suppl)
http://dx.doi.org/10.4172/2155-9562.C1.046Blockage of system xc- improves cocaine addiction in cocaine-dependence mice
Vivian Hsu
China Medical University, Taiwan
T
he cystine-glutamate antiporter or system x
c
- is a membrane-bound Na+-independent amino acid transporter which exchanges
intracellular glutamate for extracellular cysteine. Previous studies have shown that activation of system x
c
- by its activator
N-acetylcysteine (NAC) inhibits reinstated cocaine or nicotine seeking behaviors. In addition, the expression of systemx
c
- subunit xCT
in brain was up-regulated in cocaine dependence mice, but down-regulated in cocaine withdrawal mice, suggesting a dynamic change
in xCT expression and its activity during addiction. Unfortunately, system x
c
- is not the only target for NAC and all pharmacological
inhibitors commonly used to study system x
c
- activity have off-target effects. These issues raise the uncertain role of system x
c
- in
addiction. In this study, we tested xCT knockout (xCT-/-) mice for dependence-induced drinking using the chronic intermittent
cocaine-two bottle choice drinking protocol. There was significant inhibition in daily cocaine consumption in xCT-/- mice during
free-choice drinking as compared to wild type (WT) mice, indicating genetic deficiency of system x
c
- blocked cocaine dependence.
Moreover, sulfasalazine (SAS), the US Food and Drug Administration (FDA) that ㄓblocks system x
c
-, significantly attenuated the
daily cocaine consumption during free-choice drinking in cocaine-dependence mice as compared to control vehicle (DMSO). Taken
together, these findings show blockage of system x
c
- improves cocaine addiction in cocaine dependence-mice. Inhibition of system
x
c
- represents a new class of therapeutics against cocaine addiction.
Biography
Vivian Hsu is currently obtaining her Master’s Degree at China Medical University. She opts to apply for Doctorate studies in the future. She is a student of Professor
Chia-Hung Hsieh who has published more than 10 research papers in notable journals. He is currently researching on therapeutics for cocaine addictions with a
plan to go into clinical trials.
vivianhsuhw@gmail.com