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Volume 8, Issue 2 (Suppl)
J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal
Neurology 2017
March 27-29, 2017
March 27-29, 2017 Madrid, Spain
11
th
World Congress on
Neurology and Therapeutics
Linda Rosalina et al., J Neurol Neurophysiol 2017, 8:2 (Suppl)
http://dx.doi.org/10.4172/2155-9562.C1.046Neuroprotective effect of catechins gambier on beta amyloid plasma and cognitive in Dawley-Sprague as
model of Alzheimer
Linda Rosalina, Indrawati Lipoeto, Amir Darwin
and
Ellyza Nasrul
Padang State University, Indonesia
Objectives
: Alzeimer’s disease (AD) is an important social and economic issue for our societies. Patient with AD progress from stage
of mild memory impairment to complete dementia. The development of therapeutics against this severe dementia requires assessing
the effects of new drugs in animal model. An increasing body of evidence implicates both brain inflammation and oxidative stress in
pathogenesis of AD. A variety of studies have demonstrated that herbal extract and active compound of
Uncaria
are effective on the in
vitro and in vivo neurodegenerative models. Cathecin from
Uncaria gambier
Indonesian traditional herbs have been found to possess
anti inflamatory and antioxidative effect. There was no report about neuro protective effect of cathechins gambier in Dawley-Sprague
as model of Alzheimer. In the present study, we investigated the neuroprotective effect of cathechin gambier on beta amyloid-42
plasma (Aβ-42) and cognitive function of the Dawley-Sprague as animal model for Alzheimer's.
Methods
: Five groups of each 7 female, 12 weeks, Dawley Sprague, based on negative control, positive control, catechins dose 1, 2, 3.
Four groups with ovarectomy and D-galactose 500 mg/weight for 4 weeks. Four animals of each group underwent necropsy to collect
the blood for blood evaluation on the second weeks after treatment of cathechins. Terminal sacrified all groups in the 4th week after
the treatment.
Results
: Rats treatedAlzheimer showed shift to the light arms and spent long time comparedwith controls. It shows that theAlzheimer's
rat did not fear or panic, which is one of the characteristics amygdala damage. Since the amygdala also affect hypocampus memory’s
performance.They showed decreased the ability of spatial memory from the 2nd week of giving D-galactose and ovarectomy, but then
they showed visible improvement of spatial memory in the 4th weeks. Trends of increasing in movement of group treated with high
cathechins dose showed an improvement of locomotion. At the end of study, cathechins reduced the level of soluble beta amyloid 42
plasma. Low level of Aβ is required to set up and maintain the plasticity of sinaps and to improve cognitive function.
Conclusions
: The result of the present study supports the concept of neuroprotective effect of cathechin gambier on beta amyloid
plasma and cognitive function.
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