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conferenceseries.com
Volume 7, Issue 4 (Suppl) J Nephrol Ther 2017
ISSN: 2161-0959 JNT, an open access journal Nephrology & Urology 2017
July 06-07, 2017
JULY 06-07, 2017 KUALA LUMPUR, MALAYSIA
12TH ANNUAL CONFERENCE ON
Nephrology & Urology
Effectivity of Chronic Kidney Disease Epidemiology collaboration (CKD-Epi) and modification of
diet on renal disease (MDRD) as determination of chronic kidney disease’s stage: An evidence-based
case report
Vidhia Umami and Zharifah Fauziyyah Nafisah
University of Indonesia, Indonesia
S taging of Chronic Kidney Disease (CKD) is based on the Glomerolus Filtration Rate (GFR). Every stage has its own
treatment. Once the GFR lowers, there could be occurence of many complications and they must be treated as soon as
possible. The gold standard of GFR count is complicated, needs long time, and expensive. Therefore, there are some equations
to result estimated GFR using some variabels: age, gender, ras, and serum creatinine, named Modification of Diet on Renal
Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EpiSCr). Since 2012, there has been a
variabel added to the CKD-Epi equations, which is cystatin C. It is still questionable, which equation between MDRD, CKD-
Epi using serum creatinine (CKD-EpiSCr), cystatin C (CKD-EpiCysC), and both of them (CKD-EpiSCr-CysC) will have the biggest
effectifity, especially for Asian ras to determine the stage of CKD. The literature search was done in PubMed, Cohcrane, and
Science Direct using five keywords and either its abbreviations or accronyms. Using inclusion and exclusions criteria, three
final articles were generated. Then, critical appraisal was done based on validity, importance, and applicability criteria. The
article from Feng J et. al., Zhu Y et. al., and Zhang M et. al. with Randomized Controlled Trial (RCT) design showed that the
three articles were valid, using the gold standard an Technetium-Diethylenetriamine Pentaacetic Acid (Tc-DTPA) imaging.
The CKD-EpiCysC and CKD-EpiSCr-CysC equations have the best sensitivity, which are good for screening CKD while the
MDRD and CKD-EpiSCr have the best specificity, which are good for diagnosis confirmation of CKD. The best accuracy
belongs to CKD-EpiCysC equation, making it great for the real stage of CKD. The best precision belongs to MDRD equation,
so it will be great for the evaluation and monitoring of the patient’s disease.
Biography
Vidhia Umami has completed her Specialist program in Internal Medicine, University of Indonesia in December 2012. She was also graduated from Faculty of
Medicine University of Indonesia, for her Medical Doctor in August 2005. She is now in Consultant program in Nephrology and Hypertension at Internal Medicine
Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General National Hospital. She worked at several hospitals in Indonesia and now actively work
in Bahkti Asih Hospital, Tangerang and also in Cipto Mangunkusumo General Hospital. She is a member of Indonesian Medical Association, Indonesian Society of
Internal Medicine, Indonesian Society of Nephrology, Indonesian Society of Hypertension, and Indonesian Transplantation Society. She has published numerous
articles and posters in several conferences throughout the world.
Vidhia Umami ., J Nephrol Ther 2017, 7:4 (Suppl)
DOI: 10.4172/2161-0959-C1-043