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conferenceseries.com
Volume 7, Issue 6 (Suppl) J Nanomed Nanotechnol
ISSN: 2157-7439 JNMNT, an open access journal Nanotek 2016
December 05-07, 2016
December 05-07, 2016 Phoenix, USA
13th International Conference on
Nanotek & Expo
Sophia Selvarajan et al., J Nanomed Nanotechnol 2016, 7:6 (Suppl)
Self-powered biosensor for direct detection of cysteine using functionalized BaTiO3 nanoparticles
Sophia Selvarajan, Nagamalleswara Rao Alluri, Arunkumar Chandrasekhar and Sang-Jae Kim
Jeju National University, South Korea
C ysteine being an essential amino acid, source of sulfide, biomarker and a precursor has vital role in homeostasis. Abnormality
in cysteine levels leads to chronic diseases such as rheumatoid arthritis, Parkinson’s disease, cardiovascular disease, Alzheimer’s
disease and adverse pregnancy outcomes. Various cysteine detection techniques have been developed based on fluorometry,
electrochemical voltammetry and fluorescence-coupled HPLC techniques involving tedious procedures limiting their practical
applications. Self-powered nano sensors are gaining interest due to its own merits such as battery less operation, portability, point
of care diagnosis, implantable applications and so on. First of its kind, direct detection and facile fabrication of cysteine responsive
film based self-powered device has been reported. NH2 functionalized BaTiO3 NPs (BT- NH2 NPs) suspended in a 3D matrix of
Agarose film (Ag) serves as the sensing element for cysteine detection. The change in surface charge properties of the film with
respect to cysteine concentrations were determined using I-V technique. The current response increased with increase in cysteine
concentrations (linear concentration range is 10 µM to 1 mM). The composite’s properties invoked interest in developing Piezoelectric
Nano-Generator (PNG) which eventually lead to the fabrication of self-powered cysteine sensor (PNG’s output voltage was used
for driving the sensor). The potential drop across the sensor was measured as a function of different cysteine concentrations in
self-powered cysteine sensor. Real time analysis was performed using urine samples. The proposed sensor has good selectivity and
detection limits down to 147 nM.
Biography
Sophia Selvarajan is currently pursuing her PhD in Department of Advanced Convergence Technology and Science at Jeju National University, South Korea. She
completed her Master of Technology in Nanotechnology at Karunya University, India and Bachelor of Technology in Biotechnology at Centre for Plant Molecular
Biology and Biotechnology, Tamil Nadu Agricultural University, India. Her research areas of interest include “Nano-biosensors, self-powered systems for theranostics
and drug delivery system.