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Volume 7
Journal of Infectious Diseases & Therapy
Infectious Diseases & Endocrinology 2019
February 27-28, 2019
February 27-28, 2019 Tokyo, Japan
Infectious Diseases, Diabetes and Endocrinology
Global Experts Meeting on
Abdul Salam M Al-Mukhtar, J Infect Dis Ther 2019, Volume 7
DOI: 10.4172/2332-0877-C2-063
Effectiveness of albendazole against viability of
Entamoeba histolytica
in experimental animals
Abdul Salam M Al-Mukhtar
University of Mosul, Iraq
Aim:
Intestinal amoebiasis is still an important health problem in developing countries of the world. One of the most issues for
future biomedical research is the development of antimicrobial resistant, in order to search for alternative new anti-amoebic
drugs. A study was carried out to evaluate the efficacy of Albendazole on the viability of
Entamoeba histolytica
clinical isolate
from human which used for experimental animals.
Method:
All experimental animal models (30 albino mice and 30 rabbits), divided into 3 groups, each group with either 10 mice
or 10 rabbits, were orally infected with
E. histolytica
(clinical isolate), then after 7 days they were given drugs (Metronidazole
or Albendazole) daily according to body weight prepared in advance for 5 days duration and in addition to the controls
without drugs. Stool specimens of each group were examined microspically for viable trophozoites and the number of these
trophozoites was counted with hemocytometer chamber, as compared to untreated and treated groups. Statistical methods
used were student t-test.
Result:
The results showed infection of
E. histolytica
was able to be initiated in rabbits only. Albendazole and Metronidazole
were highly effective (100%) on treatment of infected groups of rabbits. Trophozoites of
E. histolytica
was highly sensitive to
Albendazole (25% viability) or to Metronidazole (22.7% viability) at a dose of 400 mg/kg/day and 250 mg/kg/day, respectively
which was significant in relation to the control 500% viability. However, the differences were significant at the level (p<0.01).
Conclusion:
The present study showed that the newly used Albendazole is very effective anti-amoebic drug as Metronidazole
in rabbits.
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