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.com

Volume 5, Issue 3 (Suppl)

J Infect Dis Ther, an open access journal

ISSN:2332-0877

Infectious Diseases 2017

August 21-23, 2017

3

rd

Annual Congress on

Infectious Diseases

August 21-23, 2017 San Francisco, USA

Prevalence of

UMOD

gene

mutation among Saudi patients with kidney failure

Saleh Ahmed Alogla

1

,Hussain Gadelkarim Ahmed

1

, Rayan Mohsen Ismael

1

, Abdulkarim Ali Alqufayi

1

, Saleh Othman Alamer

1

, Hamoud Khalid

Alshaya

1

, Ibrahim Abdelmageed Ginawi

1

and

Awdah M Al-hazimi

2

1

University of Hail, KSA

2

King Abdul-Aziz University, KSA

Background:

Mutations in the uromodulin (

UMOD

)

gene

lead to a dominant hereditary renal disease, which may ultimately

result in kidney failure. Therefore, the aim of this study was to assess the burden of

UMOD

associated renal among Saudi

patients with renal failure (RF).

Methodology:

PCR amplification of 10 exons (forward and reverse) enclosed in the

UMOD

gene

is done on the patient's

genomic DNA of 103 Saudi patients with RF.

Results:

Of the 103 patients,

UMOD

gene

mutation was identified in 10/103 (9.7%).

v

UMOD

gene

mutation is relatively prevalent among Saudi patients with RF. Further evaluation of different mutations in this

gene

is important for overall assessment of its role in RF among Saudi population.

Biography

Saleh Ahmed Alogla present is a student of Medical college in University of Hail, Saudi Arabia.

Aloglasaleh@gmail.com

Saleh Ahmed Alogla et al., J Infect Dis Ther 2017, 5:3 (Suppl)

DOI: 10.4172/2332-0877-C1-026