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Volume 5, Issue 3 (Suppl)
J Infect Dis Ther, an open access journal
ISSN:2332-0877
Infectious Diseases 2017
August 21-23, 2017
3
rd
Annual Congress on
Infectious Diseases
August 21-23, 2017 San Francisco, USA
Transcriptomic, proteomic and metabolomics analysis of sexual stage development in Malaria
Utpal Tatu, Divya Beri, Balu Balan, Shweta Chaubey
and
Manish Grover
Indian Institute of Science, India
T
he malaria parasite heavily relies on secretory functions for its pathogenesis. Is the parasite is equipped with machinery to
tackle perturbations to its secretory pathway? In this talk the author will describe their study revealing a complete absence
of genes involved in the canonical unfolded protein response pathway in
Plasmodium falciparum
. Accordingly, the parasite is
unable to up-regulate endoplasmic reticulum (ER) chaperones or ER-associated degradation in response to ER stress. Global
profiling of gene expression together with proteomic and metabolomics analysis upon redox stress revealed a network of AP2
transcription factors, their targets and specific metabolites being activated and/or upregulated. The overall outcome was an up-
regulation of genes involved in protein export and the sexual stage of the parasite life cycle, culminating in gametocytogenesis.
Our results suggest that the malaria parasite uses ER stress as a cue to switch to the transmissible, sexual stage.
tatu@biochem.iisc.ernet.inJ Infect Dis Ther 2017, 5:3 (Suppl)
DOI: 10.4172/2332-0877-C1-027