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Volume 6
Journal of Infectious Diseases & Therapy
ISSN: 2332-0877
Infection Prevention 2018
December 06-07, 2018
Page 46
conference
series
.com
December 06-07, 2018 | Valencia, Spain
14
th
World Congress on
Infection Prevention and Control
Ionel Victor Pătraşcu, J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C6-053
Chicken immunological active protein (CIAP). The immunoVIP (IVIP)group of products from an
integrated perspective: Applicative research, transfer of technology, productions, clinical use
A
ctiveimmunity specialists, due to having extensive experience in the field of antibiotic resistance, have produced different
generations of antimicrobial biologicals using hen as the immunized organism and the hyperimmune egg as the source of
immunologically active proteins. The first generation of products were prepared using the I-PC-2 immunogens and the following
generations using the I-SPGA and I-Gary immunogens. The “standard” biological products obtained from hyperimmune eggs
contain up to 24 types of antibodies originating from immunization of hens with hospital-collected germs and are used in medical
programs for the prevention and treatment of infections with susceptible or antibiotic resistant bacteria. The second category of
biological products, the “personalized” ones, are prepared from samples of pathological material harvested from individual patients
The idiotype (Id) of an antimicrobial resistant bacterium (ARB) is a unique collection of antibodies produced by the immunized
organism against the bacterial antigenic determinants called idiotopes. An idiotype is specific to a particular ARB strain that
immunized the organism. Despite being proteins of the humoral immune system, the idiotypes (Ids) can be immunogenic. For
this reason ARB-specific Ids have been exploited as therapeutic immunogens in the treatment of specific ARB infected patients.
The authors are not aware of documented studies describing the use of hyperimmune eggs targeting antibiotic-resistant bacteria as
oral anti-idiotypic vaccine in human beings. We supported this hypothesis by demonstrating the capacity of human beings orally
fed hyperimmune eggs to induce systemic immune responses against the same idiotype (active immunity by passive immunity).
The first set of study was to demonstrate that chicken that were immunized with the inactivated antimicrobial-resistant bacteria
(ARB) produced specific anti-ARB antibodies; the second set of study was to demonstrate that ARB-infected patients presenting
clinical symptoms, after being fed anti-ARB hyperimmune eggs developed antibodies that were able to inhibit the binding of egg
yolk anti-ARB antibodies to the ARB (original antigen), showing that the anti-ARB antibodies raised in human beings after feeding,
were anti-anti-idiotypic antibodies [1,2]. The samples of bacterial strains and cells were collected as skin-scrapings, prostate, urine
or sputum samples from clinically affected subjects. Moreover, nasal swabs were taken to determine the nasal colonization with
Staphilococcus aureus. These samples were processed in the laboratory and used for immunization of specially bred chickens for this
program. The immune response of the immunized chickens was controlled by blood and egg samples. The chicken immunologically
active proteins (CIP) were isolated from the hyperimmune eggs and were then used for the treatment of the particular patients from
which the pathological materials originated. These technologies have been carried out for the first time in the world and they prove
that personalized biologic products may act specifically and efficiently in case of infections with specific pathogenic germs sensitive
or resistant to antibiotics. These new personalized biological products may replace antibiotics which have been proved inefficient
in each patient. The treatment with the hyperimmune egg and with the products extracted from it was well tolerated by patients for
a long period of time (at least 12 months). Activeimmunty has a telephone call center and a group of specialists who are available
for information, a clinic and laboratories specifically designed for this program, in order to prepare the described personalized
biological products.
Ionel Victor Pătraşcu
Activeimmunity srl, Romania