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Volume 6
Journal of Infectious Diseases & Therapy
ISSN: 2332-0877
Infection Prevention 2018
December 06-07, 2018
December 06-07, 2018 | Valencia, Spain
14
th
World Congress on
Infection Prevention and Control
The use of chicken immunologically active proteins (CIAP) for the treatment of bone, joint and soft
tissue infections with antimicrobial resistance (AMR) germs in Romanian patients
Costin Aurel Militarul, Patrascu Ionel Victor, Liliana Viasu, Anca Maria Petrini, Maria Serdarub
and
Ilies-Rares Preutu
Activeimmunity Srl., Romania
Introduction:
Infections with antimicrobial resistance (AMR) germs are a strong concern of present medical practice, imposing
a stringent need for efforts to identify alternative treatment approaches. Chicken Immunologically Active Proteins (CIAP)
including Immunoglobulin (Ig)-Y represent powerful tools obtained from the eggs of chickens immunized with antigens of
the hospital-isolated AMR germs (1-3). This study presents the use of CIAP in AMR infections of bones, joints and soft tissue
in Romanian patients.
Patients group:
We have performed a study on 8 patients (6 male and 2 female) aged 43 to 72 years with AMR infections of
bones, joints and soft tissue of the lower limbs and with diverse superposed debilitating pathologies (uncontrolled diabetes
mellitus, high blood pressure, atheromatous arteriopathy) that were treated orally and topically with CIAP. Patients were
subjected to thorough medical investigations including haemoleucogram, inflammatory markers, glycemia, liver and kidney
function tests, vascular imaging, lower limb radiographs, microbiological culture from wounds and pus collections. In diabetic
patients, glycemic control was acquired by insulin or oral antidiabetic drugs administration and in one patient the blood flow
to the affected lower limbs was restored by axillary-bi-iliac by-pass. Orthopedic surgery was performed in order to correct
bone and joints pathology.
Results:
The evolution was favourable after orthopedic surgery in all patients treated orally and topically with CIAP in the
absence of any simultaneous antibiotic treatment, thus salvaging the affected inferior limbs. CIAP treatment led to buildup of
bone, remodelling of soft tissue and recovery of independent ambulatory capabilities. The obtained results are very suggestive
of the immunomodulatory actions and treatment potency of CIAP products in infections with AMR germs in humans.
Costin Aurel Militarul et al., J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C6-053
Figure 1:
Salvage of inferior limb in a representative patient with diabetes mellitus, high blood pressure, bi-iliac arterial occlusion,
calcanean necrosis infected with antibiotic resistant Pseudomonas aeruginosa, after axillary-bi-iliac by-pass, necrotic bone resection,
IMUNOINSTANT MULTIPLU (CIAP) oral and topic administration, without additional antibiotic treatment