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Journal of Infectious Diseases & Therapy |ISSN: 2332-0877 | Volume 6
June 25-26, 2018 | Vancouver, Canada
3rd International Conference on
2nd International Conference on
Infection, Disease Control and Prevention
Microbial Pathogenesis & Infectious Diseases
&
Association of P2X7 1513A/C polymorphism with susceptibility to tuberculosis among sudanese
patients
Hajir Sir Elkhatim Hamid Mukhtar
National Center of Neurological Sciences, Sudan
Background: Tuberculosis is a chronic, systemic infectious disease caused by M. tuberculosis mostly infecting the lung to cause
pulmonary tuberculosis or localize in alternate body sites leading to extra-pulmonary tuberculosis (EPTB).The P2X7 receptor
expressed in a wide variety of normal and disease-associated cell types, activated by extracellular adenosine 5’-triphosphate
results in numerous events including the release of pro-inflammatory mediators, cell proliferation or death, and killing of
intracellular pathogens. A deficiency of P2X7-mediated control of mycobacterial infection within macrophages in the lung
may permit spread to extrapulmonary sites where the infection either progresses to post–primary TB disease.
Methods: One hundred and twenty tuberculosis patients with 46 apparently healthy controls were included for genotyping of
the P2X7 polymorphism using Polymerase chain reaction and restriction fragment length polymorphism (PCR –RFLP) and
confirmed by sequencing a subset of samples.
Results: This study found that the P2X7 1513A/C polymorphism is significantly associated with tuberculosis infection (CC,
AC OR=4.615, 2.058). The pulmonary tuberculosis was the most predominant in the study population but the CC, AC allele
had statistical significant association with the Extra-pulmonary tuberculosis infections (OR=2.65). Another polymorphisms
rs2230912 was detected from sequencing results may be associated with TB infections.
Conclusion: The CC genotype is associated with susceptibility to TB infections among Sudanese patients and associated with
the extrapulmonary TB. Keywords: TB, P2X7, susceptibility, pulmonary TB, Extra-pulmonary,PCR, RFLP.
Biography
Hajir is working at National center of neurological sciences, sudan & also she is the faculty of medical laboratory sciences, Al-Neelain University-Sudan and also
faculty in the department of surgery, faculty of medicine, university of khartoum-Sudan.
Hajir Sir Elkhatim Hamid Mukhtar, J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C2-041