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Journal of Infectious Diseases & Therapy |ISSN: 2332-0877 | Volume 6
June 25-26, 2018 | Vancouver, Canada
3
rd
International Conference on
2
nd
International Conference on
Infection, Disease Control and Prevention
Microbial Pathogenesis & Infectious Diseases
&
Do alcohol based hand rubs have efficacy against multidrug-resistant organisms?
De Nardo E
1
, Wilson-Edmonds S
1
, Beausoleil C, Terri Eastman T
2
, Yeik Alyssa
2
and
Macinga D
1
1
GOJO Industries Inc., USA
2
Bioscience Laboratories Inc., USA
Background:
Multidrug-Resistant Organisms (MRO) including Vancomycin-Resistant
Enterococci
(VRE),
Staphylococcus
aureus
and the new yeast
Candida auris
(MDRCA) are often passed from person to person by the contaminated hands of
caregivers.1, 6,7,8,9 Hands become contaminated by contact with patients infected with MRO or contaminated surfaces.
Cleaning hands with soap and water or use alcohol-based hand rubs (ABHR) are the main recommendation of WHO 2 for
preventing the spread of MRO in health care settings. However, the efficacy of ABHR against MRO is not well documented 3
Objectives:
Determine the efficacy of different formulations of ABHRs (gel and foam) against different strains of MDRO such
as VRE, MRSA, Klebsiella and the recent discovered multidrug-resistant yeast
Candida auris
.
Methods:
Three ABHR ranging from 62% to 70% alcohol content in gel and foam format were evaluated using a 15 second
in
vitro
Time-Kill (ASTME 2315) 4 against several strains of
S. aureus.
In addition, two formulations of ABHR (gel and foam 70%)
were tested against more than 40 strains of antibiotic susceptible and resistant bacteria. For
C. auris
a different formulation of
ABHR was also included. Statistical comparison of log10 reductions (LR) was performed using the Fisher’s LSD Test (p<0.05).
Results:
ABHR formulations gel or foam from 62-70% ethanol content, reduced all strains of bacteria antibiotic sensitive or
resistant as well as
C. auris
tested by ≥ 6 log10 (≥ 99.9999%) in 15 seconds.
Conclusions:
No differences in susceptibility to alcohol were shown by antibiotic resistant bacteria when compared to the
sensitive strains. Alcohol 60% or higher showed the same level of efficacy. The emerging multidrug-resistant yeast Candida
auris also showed complete susceptibility to the 3 formulations tested. These results support WHO recommendations for use
of ABHR by healthcare personnel for preventing the spread of MRO.
Biography
Elizabeth De Nardo. joined GOJO Industries, Inc. in March 2008 as a Senior Scientist, conducting research projects in collaboration with experts in the areas of
infection control, hand hygiene, Norovirus and Microbiome from different US Institutions. She holds a PhD in General Microbiology with expertise in Virology with
more than 20 years of experience as a researcher acquired in previous jobs.
denardoe@gojo.coDe Nardo E et al., J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C2-041