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Journal of Analytical & Bioanalytical Techniques | ISSN: 2155-9872 | Volume 9
World HPLC, Separation Techniques & Pharmacovigilance
World Analytical Chemistry & Mass Spectrometry
18th International Conference on
August 29-30, 2018 | Toronto, Canada
&
Potentiometry as a tool for monitoring of antioxidant activity
Khiena Z Brainina1, Yan E Kazakov2 and Aleksey V Tarasov1
1Ural State University of Economics, Russia
2JSC Medical Technology, Russia
The complexity of biological objects and the rapid change in their composition after sampling, the variety of compounds
of different chemical nature, possessing oxidative and antioxidant properties, make the task of its estimating extremely
important. The use of potentiometry in determining integral antioxidant/oxidant activity (AOA/OA) mainly of biological fluids
and human skin is discussed. The source of information is the electrode potential shift that occurs when the analyzed sample is
introduced into the solution of the mediator system or when the mediator system is brought into contact with the skin. Results
of analysis of blood plasma of groups of patients with different pathologies and skin studies are presented. The decrease of
AOA in patients with coronary heart disease, hypertension and malignancy, in particular, was shown. It is demonstrated an
increase in skin AOA after taking ascorbic acid, enriched by vitamins juices, as well as the application of creams containing
antioxidants. Zones of healthy people, risk and pathology are found. The findings open up new opportunities in expanding
the use of analytical chemistry in such an important field as medicine. The trends include laboratory and on-site variants, the
wearable, implementations on the way from the test tube to the smartphone.
Biography
Khiena Brainina holds a Ph.D. in chemical sciences (Ural State University, 1959), . in chemical sciences (Moscow State University, 1967) and Professor
in chemistry. More than 500 papers, abstracts and patents are published in Russian and international journals. 5 books in stripping analysis are published by
Chemistry (Russia) and Willey & Sons (USA). Main research interests are: electrochemical sensors, stripping voltammetry, environmental monitoring, flow-through
analysis, solid substance electrochemical characterization, sensors and antioxidants monitoring.
Khiena Z Brainina et al., J Anal Bioanal Tech 2018, Volume 9
DOI: 10.4172/2155-9872-C1-027