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Journal of Analytical & Bioanalytical Techniques | ISSN: 2155-9872 | Volume 9
World HPLC, Separation Techniques & Pharmacovigilance
World Analytical Chemistry & Mass Spectrometry
18
th
International Conference on
August 29-30, 2018 | Toronto, Canada
&
Applications of UPLC-MS QTOF in structural elucidation of small molecules
T
he structural elucidation of small molecules by high-resolution mass spectrometry plays important roles in development
and quality control of pharmaceuticals and medical devices. Trace amounts of small molecules can be present in forms
of impurities, by-products or degradation products, etc. It is often difficult to separate and fractionate enough quantities of
these analytes for conventional structural analysis by NMR and FTIR. Recent advances in instrumentation and software of
UPLC-MS QTOF with MS/MS fragmentation capability can give structural insight into molecules of interest and in many cases
offer structure candidates at high confidence. This presentation will use several practical examples in the analysis of synthetic
compounds and identification of impurities associated with pharmaceuticals and medical devices to illustrate the convenience
and power of UPLC-QTOF high-resolution mass spectrometry.
Biography
Peng Chen received a Ph.D. in Analytical Chemistry from Indiana University in 1998 and a M.S. in Organic Chemistry from the University of Louisville in 1994. His
graduate research includes the introduction of osazones as MALDI matrices for carbohydrate analysis and the structural elucidation of fluorescent aging markers.
He has been working in various chemical industry sectors in the fields of chromatography and mass spectrometry. His work in recent years at Chemic Labs Inc.
involves structural elucidation of small molecules in pharmaceuticals and medical devices by high-resolution QTOF mass spectrometry.
pchen@chemiclabs.comPeng Chen
Chemic Labs Inc., USA
Peng Chen, J Anal Bioanal Tech 2018, Volume 9
DOI: 10.4172/2155-9872-C1-026