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Volume 8, Issue 5 (Suppl) J Blood Disord Transfus, an open access journal
ISSN:2155-9864 Hematology 2017
November 08-09, 2017
November 08-09, 2017 | Las Vegas, USA
11th International Conference on
Hematology & Hematological Oncology
Direct antiglobulin reactions in Plasmodium falciparum parasitized patients in Sokoto, North-Western,
Nigeria
Augustine Okwesili
Usmanu Danfodiyo University Sokoto, Nigeria
Background & Aim: Malaria is a global public health problem affecting people particularly in tropical and sub-tropic regions of the
world. Immune mediated hemolysis is thought to occur in malaria infection. The aim of this study was to investigate the incidence of
direct antiglobulin positivity among 100 patients with P. falciparum malaria in Sokoto, North Western, Nigeria.
Method: Evidence of immune mediated hemolysis with characteristic positive direct Coombs test was investigated among a cohort
of 100 Plasmodium falciparum parasitized subjects aged 6 to 45 years and mean age 26.9±8.25 years, made of 56 males (56%) and 44
females (44%) resident in Sokoto, North Western, Nigeria.
Result: Amongst the 100 subjects with uncomplicated malaria infection, 3 (3%) had a positive Direct Antiglobulin Test (DAT). The
incidence of positive DAT was concentrated among subjects in the 6-15 years age groups (p=0.001). There are no gender-related
differences in the incidence of positive DAT among the subjects.
Conclusion: These findings indicate that a positive DAT is common in Plasmodium falciparum parasitized Nigerians. Malaria-related
positive DAT may be responsible for the anemia seen in patients with malaria. There is the need for the routine monitoring of malaria
parasitized subjects, particularly those with anemia in the area.
Biography
Augustine Okwesili has completed his MSc from the Usmanu Danfodiyo University Sokoto, Nigeria. He is a Lecturer in the Department of Hematology in the same university
and has published more than 27 papers in different journals of medicine both internationally and locally.
Augustine Okwesili, J Blood Disord Transfus 2017, 8:5 (Suppl)
DOI: 10.4172/2155-9864-C1-028