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Volume 7, Issue 3 (Suppl) Otolaryngol (Sunnyvale), an open access journal
ISSN:2161-119X Head, Neck and Plastic Surgery 2017
June 19-20, 2017
June 19-20, 2017 Philadelphia, USA
5th Global Summit and Expo on
Head, Neck and Plastic Surgery
Pleomorphic hyalinizing angietactic tumors: Recognizing a novel source of cancer in the upper
extremity
Johnny Ionut Efanov, Katherine Larose and Michele Tardif
University of Montreal, Canada
Statement of the Problem: Soft tissue masses of the upper extremity often represent benign pathological entities, but the
astute hand surgeon should use precaution when the possibility of malignancy arises. In the differential diagnosis, one needs
to consider pleomorphic hyalinizing angiectactic tumors (PHAT), a novel pathology with increasing reports in the literature.
The aim of this study is to report a case of PHAT in the hand and to describe diagnostic findings and management from a
systematic review.
Methodology &Theoretical Orientation: We report a case of PHAT and conducted a systematic review of the literature for all
published data on diagnosis and management of this novel entity. Publications from 1965 to 2016 were selected from databases
such as PubMed/Medline, Cochrane Review and Google Scholar. Collected data included patient characteristics, anatomical
sites of predisposition, tumor sizes, clinical signs, imaging findings, treatment options and recurrence. Results are reported as
means and interquartile ranges.
Findings: In total, there have been 48 publications on PHAT, but only 8 reported it in the upper extremity including 11 patients.
Tumor sizes ranged from 26 cm to 4 cm in largest diameter with clinical findings significant for pain on direct palpation in
91% of cases. Treatment strategies include surgical excision with wide margins (91%) and radiotherapy (9%), without any
chemotherapy. No local recurrences have been reported for 10 years.
Conclusion & Significance: Pleomorphic hyalinizing angiectactic tumors are rare soft tissue masses that can arise in the upper
extremity. Early recognition of clinical signs and surgical resection with wide margins has not resulted in recurrence so far.
Otolaryngol (Sunnyvale) 2017, 7:3 (Suppl)
DOI: 10.4172/2161-119X-C1-017