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.com
Volume 7, Issue 3 (Suppl)
Otolaryngol (Sunnyvale), an open access journal
ISSN:2161-119X
Head, Neck and Plastic Surgery 2017
June 19-20, 2017
June 19-20, 2017 Philadelphia, USA
5
th
Global Summit and Expo on
Head, Neck and Plastic Surgery
The role of HPV infection in oral and larynx lesions
Avlonitou Eirini
Iaso General Hospital, Greece
T
he precancerous lesions in the oral cavity mucosa are leukoplakia and erythroplakia. The involvement of HPV in these
lesions is under investigation. Human papilloma viruses (HPVS) are epitheliotropic and infect cuntaneous or mucosal
squamous epithelium depending on their genotype. Based on their association with carcinoma they are divided into high-
risk types (HPV 16, 18, 31, 33 and 35) and into low-risk types (HPV 6, 11, 13 and 32). Studies have demonstrated that the
prevalence of HPV in nondysplastic and in dysplastic leukoplakias is 20.2% and 26.2% respectively and the predominant HPV
types in oral leukoplakia were (HPV 6/11, 55.8%) followed by (HPV 16/18, 28.2%). The incidence of HPV 16/18 is not different
among patients with mild, moderate and severe dysplasia but HPV-16 is predominant in oral and oropharyngeal squamous cell
carcinoma (68.2% and 86.7% respectively). Despite the fact that many studies have reported the presence of HPV DNA in oral
leukoplakias; however, there is not enough evidence to prove correlation among HPV and oral leukoplakia or its progression
to carcinoma. Regarding the oral erythroplakia there are few data in the literature but from a research, it was found a high
association with HPV infection (50%) in a sample of 10 patients with this lesion. The relationship between HPV infection
and laryngeal dysplasia is still unknown but there is a probability that HPV is a cofactor in the malignant progression of these
lesions.
Biography
Avlonitou Eirini is an ENT Doctor of Athens Medical School in Greece. She has completed her PhD in Sleep Medicine and has expertise in the management
of obstructive sleep apnea syndrome in children and adults. She has number of publications in Greek and international journals in the subjects of rhinology,
neurotology, sleep medicine and pediatric otorhinolaryngology.
eavlonitou@hotmail.comAvlonitou Eirini, Otolaryngol (Sunnyvale) 2017, 7:3 (Suppl)
DOI: 10.4172/2161-119X-C1-017