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Volume 7, Issue 10 (Suppl) Gynecol Obstet (Sunnyvale), an open access journal
ISSN: 2161-0932 Gynecology 2017
October 02-04, 2017
4th International Conference on
Gynecology & Obstetrics
October 02-04, 2017 Barcelona, Spain
Early ultrasound screening for fetal malformations in the second pregnancy after combined modality
treatment for Hodgkin’s disease: A case report
Jordancho Ivanov
Clinical Hospital Acibadem Sistina, Skopje, Macedonia
Introduction: Therapeutic progress in HD has led to a high rate of cure, but at the expense of some side effects. Abnormalities
reported so far are: cardiac toxicity, pulmonary toxicity, endocrinal failure, second cancers and congenital malformations. Although
several studies reported in the literature showed no or slightly increased risk of congenital abnormalities among newborns of women
previously treated for Hodgkin’s disease compared with the general population, abnormalities do occur and sometimes they are very
odd and difficult.
Case Report: We report a case of female patient, 25 years old, Macedonian, presented with Hodgkin’s disease, subtype nodular
sclerosis, stage IIIA. The patient received chemotherapy according to ABVD protocol-6 cycles. Thereafter she received mantle field
radiation with 3600 cGy. She was followed for the next 36 months and than she become pregnant.
Clinical Cases of Summary Results: Ultrasound confirmed a normal fetus in first pregnancy during controls. A normal female
baby was born with Caesarean Section at term. Clinical assessment in the follow-up period showed normal development. Also
the mother was assessed regularly and was free of disease. The next pregnancy occurred 87 months after completion of treatment.
At 13th gestational week ultrasound assessment revealed malformations and induced abortion was suggested. A male fetus with
malformations on the head such as proboscis, cyclopia and omphalocele on the front abdominal wall containing liver and small
bowels was found. After induced abortion the autopsy report from the Institute of Pathology was: male fetus with malformations on
the head like proboscis and cyclopia (one eye beneath proboscis), and omphalocele on the frontal abdominal wall containing liver
and small bowels. Other findings were normal. The patient has been followed-up regularly until now. She is disease free, with no
more pregnancies.
Conclusions: We consider this case important in bringing the potential late side-effect to the attention of both patient and doctors.
They should be alert for the risk of congenital abnormalities in newborns of women previously treated for Hodgkin’s disease,
especially with combined modality treatment, and should check for them during pregnancy, at birth, in early childhood or in
adulthood. Treatment with chemotherapy, radiation therapy or both may have adverse effects on germ cell survival, fertility and
health of offspring. Congenital abnormalities occur in 3-5% of all live births and the possibility of an increased risk of congenital
abnormalities in newborns cannot be ignored.
Biography
Dr.Jordancho Ivanov is specialized in Gynecology and Obstetrics at the Medical Faculty in Skopje University of Saints Cyril and Methodius- Skopje, Republic of
Macedonia
Jordancho Ivanov, Gynecol Obstet (Sunnyvale) 2017, 7:10(Suppl)
DOI: 10.4172/2161-0932-C1-021