global-physiotherapy-2016_posters-accepted-abstracts

10 / 16

Page 54
Global Physiotherapy 2016
November 17-18, 2016
Volume 6 Issue 6(Suppl) J Nov Physiother
ISSN: 2165-7025 JNP, an open access journal
conferenceseries .com
November 17-18, 2016 Atlanta, USA
Global Physiotherapy Congress
J Nov Physiother 2016, 6:6(Suppl)
A review of the short form health survey version 2
Hasan Alkhawaldeh1, Abdullah Alkhawaldeh2, Omar ALOmari2, Mohammed AL Bashtawy3, Jamal Qaddumi4, Khaled Waleed Bader2 and Muwafaq
Al-momani5
1Jordan University of Science and Technology, Jordan
2Jerash University, Jordan
3AL al-Bayt University, Jordan
4An-Najah National University, Palestine
5Al-Hussein Bin Talal University, Jordan
Background: The short form health survey version 2 (SF-12v2) is a commonly used measure of HRQOL. But, it has received
much less psychometric attention.
Aim: The aim of this study is to review research articles that used SF-12v2 survey.
Method: In this study, sage data base were searched and 12 articles were revealed using of SF-12v2, sample description, testing
reliability or validity, and date of publishing (within the last 10 years).
Results: SF-12v2 was used on diverse age groups of participants. Cronbach's alpha coefficients for the tool were ranged from
0.60 to 0.87, which support the internal consistency reliability. The convergent validity of the SF-12v2 was supported in some
of the research.
Recommendations: Some recommendations were emerged to guide the future research.
Low frequency sonophoresis mediated transdermal and intradermal delivery of ketoprofen
Herbert L Silver
Mercer University, USA
Purpose: The objective of this study was to test low frequency sonophoresis as an active enhancement technology for
transdermal and topical delivery of ketoprofen and to optimize ultrasound parameters for delivery.
Methods: Sonophoresis was carried out with a sonicator operating at 20 KHz frequency and intensity of 6.9 W (Sonics
VCX 500, Sonics and Materials, Newtown, CT). Donor formulation was saturated solution of ketoprofen in 50 percent
propylene glycol containing 3.5 mg/ml drug. Vertical Franz diffusion cells were used to study transdermal and topical delivery
of ketoprofen in vitro. Permeation studies were carried out on excised hairless rat skin over a period of 24 hours. Ultrasound
application time, duty cycle and coupling medium were optimized. Aluminum foil pitting was carried out to confirm acoustic
cavitation as the mechanism of enhanced sonophoretic delivery. Transepidermal water loss measurements (TEWL) were
performed to measure the extent of barrier disruption following sonophoresis. Confocal microscopy was used to visualize dye
penetration through sonophoresis treated skin.
Results: Application of ultrasound (2 minutes, 1% SLS coupling medium) significantly enhanced permeation of ketoprofen
from 74.87±5.27 µg for passive delivery to 491.37±48.78 µg for sonophoresis. The lag time for delivery reduced
from 6 hours for passive permeation to 2 hours for sonophoresis. Drug levels in underlying skin layers increased from
34.69±7.25 µg following passive permeation to 175.04±20.56 µg following sonophoresis. TEWL increased from 31.6±0.02
(passive) to 69.5±12.60 (optimized sonophoresis conditions) indicating disruption of barrier properties. Confocal microscopy
images depicted enhanced dye penetration through sonophoresis treated skin hence confirming barrier disruption.
Conclusions: Low frequency sonophoresis with optimized ultrasound parameters can be effectively used to actively enhance
transdermal and topical delivery of ketoprofen.