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Volume 7, Issue 7 (Suppl)
J Gastrointest Dig Syst
ISSN: 2161-069X JGDS, an open access journal
Gastroenterologists 2017
December 14-15, 2017
Page 16
Notes:
conference
series
.com
December 14-15, 2017 Dubai, UAE
11
th
World
Gastroenterologists Summit
An overview of potential pathophysiological mechanisms in food hypersensitivity
M
ajorityof thepatientswithperceived foodhypersensitivityhave irritable bowel syndrome (IBS) anda significant proportion
of IBS patients also attribute their gastrointestinal complaints to food items. Different factors such as disturbed intestinal
fermentation, enteric dysmotility, post-infectious changes and altered microbial flora in the colon as well as psychological
disturbances likely play a role in the pathophysiology and symptoms generation in patients with food hypersensitivity. The
management of these patients should be interdisciplinary. The results of our more than 10 years’ interdisciplinary research
program dealing with such patients showed that food allergy was seldom diagnosed despite extensive examinations. The
majority of the patients fulfilled the diagnostic criteria for irritable bowel syndrome. In addition, most suffered from several
extra-intestinal health complaints and had considerably impaired quality of life. However, psychological factors could explain
only approximately 10% of the variance in the patients’ symptom severity and 90% of the variance thus remained unexplained.
Intolerance to low-digestible carbohydrates was a common problem and abdominal symptoms were replicated by carbohydrate
ingestion. A considerable number of patients showed evidence of immune activation by analyses of B-cell activating factor,
dendritic cells and “IgE-armed” mast cells. In addition, a number of other studies in these patient groups indicate that local,
systemic and mucosal immune systems are activated. During the presentation, the role of these potential factors including
management of these patients will be reported in patients with perceived food hypersensitivity.
Biography
Gulen Arslan Lied is a Consultant Gastroenterologist and Professor at the Haukeland University Hospital, Department of Gastroenterology in Bergen, Norway. She
has engaged in active research since 2001 and she supervises many PhD candidates and master students in field of gastroenterology and human and clinical
nutrition. Her fields of interests include clinical trials in interactions between nutrition and gut microbiota, inflammation, functional gastrointestinal disorders (irritable
bowel syndrome) including nutritional and allergo-immunological aspects, food allergy and intolerance (food hypersensitivity) and experimental studies (food allergy
model in mice and colitis models induced by DSS or TNBS in rats).
Gulen.Arslan@uib.noGulen Arslan Lied
Haukeland University, Norway
Gulen Arslan Lied, J Gastrointest Dig Syst 2017, 7:7 (Suppl)
DOI: 10.4172/2161-069X-C1-061